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Abstract
Original Article
Plasma (1→ 3) -β -D-glucan Level in Allergic Bronchopulmonary Aspergillosis
Kazuhiko Shibata1) Masaki Fujimura2)
1)Department of Respiratory Medicine, Koseiren Takaoka Hospital, Takaoka, Japan
2)Department of Internal Medicine (III), Kanazawa University School of Medicine, Kanazawa, Japan
ABSTRACT
We measured the plasma (1→ 3) -β -D-glucan (β -DG) levels in patients with allergic bronchopulmonary aspergillosis (ABPA) and compared their temporal changes with those of serum IgE and eosinophil counts in the peripheral blood. The subjects were three ABPA patients who were newly diagnosed or had had a relapse between May 1998 and April 1999. Before treatment, all three cases showed high plasma β -DG values, which declined following corticosteroid treatment with or without oral itraconazole. In two cases, the β -DG values rose again on relapse. β -DG values showed a tendency to change in parallel with IgE, although they moved in the opposite direction after a relapse in one case. The present findings suggest that the plasma β -DG level may be a useful follow-up indicator of the infectious aspect of this disease.
KEYWORDS
Allergic bronchopulmonary aspergillosis (1→3)-β-D-glucan Itraconazole IgE Fungal infection
Received 平成12年7月28日
JJRS, 39(6): 383-388, 2001
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