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Abstract
Case Report
Hypogammaglobulinemia associated with thymoma (Good syndrome) similar to diffuse panbronchiolitis
Takahiro Tsuburai1) Kunihiko Ikehara2) Shunsuke Suzuki1) Takeshi Shinohara1) Wataru Mishima1) Akihiro Tagawa1) Masaru Itou1) Naoki Miyazawa1) Harumi Nishiyama1) Akira Shoji1) Motoyoshi Suzuki1) Takeshi Matsuse3) Yoshiaki Ishigatsubo1)
1)First Department of Internal Medicine, Yokohama City University School of Medicine, 2)Department of Internal Medicine, Chigasaki Municipal Hospital, 3)Department of Respiratory Medicine, Yokohama City University Medical Center
ABSTRACT
A 65-year-old woman complained of dyspnea and a productive cough after surgical treatment and irradiation therapy for thymoma. Chest radiography and high-resolution computed tomography showed small nodules in centrilobular lesions in all of both lung fields, but predominantly in the lower fields. In addition, blood tests showed hypogammaglobulinemia. Chronic sinusitis, mild hypoxemia, severe obstructive impairment and the pathological findings of bronchiolitis led to a diagnosis of sinobronchial syndrome caused by Good syndrome. Treatment with oral erythromycin 600mg/day was started. After 6 months, the patient improved both clinically and radiologically. Low-dose, long-term treatment with erythromycin was effective against sinobronchial syndrome caused by Good syndrome.
KEYWORDS
Sinobronchial syndrome GOOD syndrome erythromycin
Received 平成15年1月23日
JJRS, 41(6): 421-425, 2003
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