Full Text of PDF (292k)
Article in Japanese
Abstract
Case Report
A case of interstitial pneumonia induced by an ACE inhibitor (temocapril hydrochloride)
Yasuhiko Kitasato1) Yukari Ikedo2) Kazuhiko Yamada2) Yusuke Mizoguchi2) Tomoaki Hoshino1) Hisamichi Aizawa1)
1)First Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka 830-0011, Japan
2)Department of Respiratory Medicine, Yame General Hospital, 540-2 Takatsuka, Yame, Fukuoka 834-0034, Japan
ABSTRACT
A 51-year-old woman who had been treated for years for rheumatoid arthritis presented with a persistent dry cough and shortness of breath three weeks after administration of the ACE inhibitor temocapril hydro-chloride against essential hypertension. Chest radiography and computed tomography showed diffuse reticular shadows and ground-grass opacities in both lung fields. Bronchoalveolar lavage fluid analysis showed an increase of lymphocytes and CD8+ T cells (93.3% of lymphocytes), and a decrease of the CD4/8 ratio of the T cell subset (0.04). Histopathological analysis of trans-bronchial lung biopsy specimens showed infiltration of lymphocytes into the alveolar septa and exudation of alveolar macrophages, signs characteristic of interstitial pneumonia. A drug lymphocyte stimulation test was positive for temocapril, but negative for other drugs. On the basis of these findings, we diagnosed temocapril hydrochloride-induced interstitial pneumonia.
KEYWORDS
Temocapril hydrochloride Angiotensin-Converting Enzyme Inhibitors Drug-induced pneumonia Drug lymphocyte stimulation test
Received 平成15年2月15日
JJRS, 41(9): 660-665, 2003
Copyright © The Japanese Respiratory Society All Rights Reserved.