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Article in Japanese
Ct findings of drug-induced pneumonitis -Characteristic CT findings by histological group and subgroup-
Hidekazu Matsushima1) Noboru Takayanagi1) Daido Tokunaga1) Yuri Maeno1) Nagato Sato1) Kazuyoshi Kurashima1) Mikio Ubukata1) Tsutomu Yanagisawa1) Yutaka Sugita1) Yoshinori Kawabata2), Minoru Kanazawa3)
1)Department of Respiratory Medicine, 2)Pathology, Saitama Cardiovascular and Respiratory Center. 3)Department of Respiratory Medicine, Saitama Medical School.
1696 Itai, Kounan, Ohsato, Saitama, 360-0105, Japan
We examined the chest CT results of 27 cases of drug-induced pneumonitis. We classified the subjects into 3 groups in accordance with the clinicopathological findings: eosinophilic pneumonia (EP) group (5 cases), diffuse alveolar damage (DAD) group (3 cases), and interstitial pneumonia (IP) group (19 cases). We evaluated the CT findings in each group, and made a further subclassification. In the EP group, the CT findings were subdivided into two, namely, type A, with diffuse distribution consistent with CT finfings of acute eosinophilic pneumonia; and type B, with subpleural distribution consistent with chronic eosinophilic pneumonia. In the DAD group, the CT findings were diffuse distribution of mixed ground-glass attenuation and air-space consolidation, with or without traction bronchiectasis, and without shrinking of the lung. In the IP group, the CT findings were subdivided into 3, namely type A, with ground-glass attenuation dominant, without traction bronchiectasis or shrinking of the lung, consintent with the CT findings of IP without fibrosis; type B, with air-space consolidation dominant, with traction bronchiectasis and shrinking of the lung, consistent with the CT findings of IP with fibrosis; and type C with multiple nodules dominant. Radiological differentiation of the DAD group from IP-type B may be possible by the presence or absence of a shrinking lung pattern. We concluded that the subgroups of CT findings in drug-induced pneumonitis may be useful for diagnosis of this disease, and for prognosis.
Drug-induced pneumonitis Chest CT findings Histologic group Subtypes
Received 平成15年7月7日
JJRS, 42(2): 145-152, 2004