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Article in Japanese
Abstract
Original Article
Therapeutic drug monitoring of cyclosporine MEPC (Neoral) therapy for interstitial pneumonia
Tetsuro Inoue Eisaku Tanaka Terufumi Kato Minoru Sakuramoto Masayoshi Minakuchi Yuji Maeda Ko Maniwa Kunihiko Terada Yoshio Taguchi
Department of Respiratory Medicine, Tenri Hospital
200 Mishimacho, Tenri, Nara, 632-8552, Japan
ABSTRACT
It is widely recognized that the area under the concentration-time curve (AUC) correlates with the clinical effects of cyclosporine MEPC (Neoral) therapy and adverse reactions to it. In this study, we investigated which single blood-level measurement had correlated best with AUC in interstitial pneumonia therapy. Neoral was prescribed in ten cases of interstitial pneumonia. We measured the concentration during the 4 hours following its administration and calculated AUC0-4 (AUC 0-4 hr). The concentration after 2 hours of administration (C2) correlated best with AUC (r2=0.71). This result suggests that C2 monitoring would be a better predictor for AUC than C0 (trough level) monitoring in interstitial pneumonia therapy.
KEYWORDS
Cyclosporin (CyA) Interstitial pneumonia Neoral Therapeutic drug monitoring (TDM) Area under the concentration-time curve (AUC)
Received 平成15年8月4日
JJRS, 42(2): 153-157, 2004
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