A case of tracheobronchopathia osteochondroplastica in which osteoclast was observed
Masahiro Shinodaa Masaharu Shinkaia,b Yuu Harab Shuichi Kawanob Takeshi Kanekoa Akihiko Kawanab
aRespiratory Disease Center, Yokohama City University Medical Center
bDivision of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine 2, National Defense Medical College
This case was a 69-year-old woman, hospitalized as a result of fever and bloody sputum. Bronchofiberscopy, aiming to find the source of bleeding, revealed beaded pale-yellow elevated lesions that lined along tracheal rings. A histological examination of biopsy specimens of these sites demonstrated bony and bone-marrow tissue with osteoblast and osteoclast, which is consistent with tracheobronchopathia osteochondroplastica. Raised nodules in tracheal lumen were shown by three dimensional computed tomography (3DCT). Endoscopic views revealed no source of bleeding, but mild bronchiectasis at the middle lobe and lingular inferius and consolidation around them were seen, which implied that some infections of the bronchiectatic region were causing fever and bloody sputum. Because she was afflicted with chronic sinusitis and bronchiectasis, the patient was diagnosed with sinobronchial syndrome. This suggests that sinobronchial syndrome may be involved in the development of tracheobronchopathia osteochondroplastica. Few reports have been made of tracheobronchopathia osteochondroplastica following an examination that focused on osteoclast. This case may offer valuable insights into the etiology of tracheobronchopathia osteochondroplastica.
Tracheobronchopathia osteochondroplastica Osteoclast Sinobronchial syndrome Bronchiectasis
Received 11 Nov 2011 / Accepted 2 Apr 2012
AJRS, 1(7): 553-557, 2012