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Article in Japanese
Clinical utility of QuantiFERON®-TB Gold assay on pleural fluid for the diagnosis of tuberculous pleurisy
Takashi Shimizua Katsuhiro Kuwabaraa Yuka Kimuraa Naho Matsuyamaa Akira Okadab Naoya Matsumotoa Takehiro Watanabeb Hiromi Miyaoa Yasuharu Saitoa Tetsuro Ohdairaa
aDepartment of Respiratory Medicine, Nishi-Niigata Chuo National Hospital
bDepartment of Respiratory Surgery, Nishi-Niigata Chuo National Hospital
Conventional methods for diagnosing tuberculous (TB) pleurisy require either an invasive procedure or long periods of time. We performed QuantiFERON®-TB Gold (QFT-3G) tests on pleural fluid and evaluated a diagnostic utility for distinguishing between TB pleurisy and non-TB pleural effusion. The QFT-3G tests and adenosine deaminase assays were performed on pleural fluid from 9 patients with TB pleural effusion and 35 patients with non-TB pleural effusion. The interferon-γ concentrations in the negative control samples were significantly higher in the TB pleurisy group than in the non-TB pleural effusion group. The values were all higher than 3.2 IU/ml in the 9 TB pleurisy group (median: 7.0 IU/ml). On the contrary, the values were all less than 0.7 IU/ml in the 35 non-TB pleural effusion group (median: 0.07 IU/ml). These findings suggest that the pleural fluid QFT-3G assay could be an accurate and prompt method for diagnosing TB pleurisy.
Tuberculous pleurisy Tuberculosis Pleural effusion QuantiFERON
Received 30 Dec 2013 / Accepted 17 Mar 2014
AJRS, 3(4): 519-524, 2014