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Article in Japanese
Clinical utility of interferon-γ assays performed with QuantiFERON®-TB gold on pleural fluid for the diagnosis of tuberculous pleurisy
Takashi Shimizua Katsuhiro Kuwabaraa Junko Babaa Naho Matsuyamaa Naoya Matsumotoa Takehiro Watanabeb Hiroshi Moriyamaa Hiromi Miyaoa Yasuharu Saitoa Tetsuro Ohdairaa
aDepartment of Respiratory Medicine, Nishi-Niigata Chuo National Hospital
bDepartment of Respiratory Surgery, Nishi-Niigata Chuo National Hospital
Conventional methods for diagnosing tuberculous (TB) pleurisy require either an invasive procedure or long periods of time. We performed interferon-γ (IFN-γ) assays on pleural fluid and evaluated a diagnostic utility to distinguish between TB pleurisy and non-TB pleural effusion. Interferon gamma levels were measured by QuantiFERON®-TB gold (QFT-3G) tests. The tests and adenosine deaminase assays were performed on pleural fluid from 26 patients with TB pleural effusion and 99 patients with non-TB pleural effusion. The IFN-γ concentrations in the negative control samples were significantly higher in the TB pleurisy group than in the non-TB pleural effusion group. The sensitivity of the test was 100.0% and the specificity was 99.0%, using a 1.7 IU/ml cutoff point. These findings suggest that the pleural fluid IFN-γ assay could be an accurate and prompt method for diagnosing TB pleurisy.
Tuberculous pleurisy Tuberculosis Pleural effusion QuantiFERON Interferon-γ
Received 28 Oct 2016 / Accepted 6 Jan 2017
AJRS, 6(3): 122-128, 2017