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Article in Japanese
A case of drug-induced pneumonitis by dietary supplement containing Agaricus during clinical course of squamous cell lung cancer
Hiroaki Muranoa Sumito Inoueb Yoshikane Tokairinb Akira Igarashib Yoko Shibatab Isao Kubotab
aPostgraduate Clinical Training Center, Yamagata University Hospital
bDepartment of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine
A 70-year-old man had for two months taken a dietary supplement containing Agaricus as followup after an operation for lung cancer. He was admitted to the hospital because of fever. Although he was diagnosed as pneumonia and treated by antibiotic, his symptoms did not improve. A chest CT scan revealed ground-glass attenuations with some small patchy consolidations in the left lung, and increasing total cell counts and lymphocytes in bronchoalveolar lavage fluid were observed. Because the results of a drug lymphocyte stimulation test against Agaricus were positive, we diagnosed him as drug-induced pneumonitis associated with Agaricus. He was treated with oral corticosteroid, and his symptoms and lung abnormalities improved. To our knowledge, few cases of lung injury induced by Agaricus have been reported. We need to consider that many patients with cancer take dietary supplements.
Lung cancer Drug-induced lung injury Agaricus blazei Murill Dietary supplement
Received 14 Mar 2016 / Accepted 26 Dec 2016
AJRS, 6(3): 186-189, 2017