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Article in Japanese
A case of Good syndrome accompanied by a macrolide-resistant diffuse panbronchiolitis-like symptoms
Masamitsu Shimizu Yoshinobu Saito Yukiko Miura Yuji Minegishi Arata Azuma Akihiko Gemma
Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School
The patient was a 50-year-old woman diagnosed with myasthenia gravis and thymoma who was being treated with radiochemotherapy, steroid administration, and immunosuppressive therapy after thymectomy. Approximately 5 years after the diagnosis, productive cough developed and centrilobular granular shadows in both lung fields were observed by chest contrast-enhanced computed tomography (CT). Diffuse panbronchiolitis (DPB) was ruled out by a negative HLA-B54 gene test result. Her condition was associated with hypogammaglobulinemia due to a decreased B-cell count.
Good syndrome complicated by DPB-like symptoms was diagnosed. We report this case because macrolide-resistant cases, such as that of our current patient, are rare.
Good syndrome Hypogammaglobulinemia Diffuse panbronchiolitis HLA-B54 gene Macrolide therapy
Received 27 Jul 2017 / Accepted 13 Feb 2018
AJRS, 7(3): 171-176, 2018