A case of lymphomatoid granulomatosis with sarcoidosis that was difficult to diagnose
Haruka Motohashi Mayuko Ishiwari Yuta Kono Yuki Yamaguchi Reimi Mizushima Shinji Abe
Department of Respiratory Medicine, Tokyo Medical University
The patient was a 68-year-old man. During follow-up after chemoradiotherapy for prostate cancer, an enlarged intra-abdominal lymph node was noted. He underwent an upper gastrointestinal endoscopy and was suspected of having low-grade B-cell lymphoma, but a definitive diagnosis was not made. Bilateral pulmonary nodules appeared, and the patient was referred to the Department of Respiratory Medicine.
An inguinal lymph node biopsy with accumulation on FDG-PET showed no evidence of malignancy, but an epithelioid granuloma was detected. The patient underwent video-assisted thoracic surgery for a rapidly enlarging pulmonary lesion, leading to a diagnosis of lymphomatoid granulomatosis. Lymphoma may develop during the course of sarcoidosis, and prioritizing lesions considered to be highly active may aid in early diagnosis
Lymphomatoid granulomatosis Sarcoidosis-lymphoma syndrome
Received 6 Aug 2024 / Accepted 7 Aug 2024
AJRS, 13(6): 296-300, 2024