Annals of The Japanese Respiratory Society:A case of extensive-disease small cell lung cancer with Lambert-Eaton myasthenic syndrome successfully treated with platinum doublet and atezolizumab therapy

Abstract

Article in Japanese

Case Report

A case of extensive-disease small cell lung cancer with Lambert-Eaton myasthenic syndrome successfully treated with platinum doublet and atezolizumab therapy

Juri Kawasaki^a Sakae Fujimoto^a Hiroyuki Kamiya^a Takanori Miyoshi^b

^aDepartment of Respiratory Medicine, Yuai Memorial Hospital
^bDepartment of Respiratory Surgery, Yuai Memorial Hospital

ABSTRACT

A 67-year-old man was referred to our hospital with anorexia. As a result of detailed examination, he was diagnosed with small cell lung cancer. Additionally, gait impairment from lower limb muscle weakness, elevation of anti-P/Q-type voltage-gated calcium channel antibodies, and a waxing phenomenon during a 30-Hz stimulation on repetitive stimulation test led to a diagnosis of Lambert-Eaton myasthenic syndrome. Four cycles of platinum doublet and atezolizumab therapy resulted in a complete response. His muscle symptoms remained unchanged. Maintenance atezolizumab still continues today without tumor relapse or worsening of muscle symptoms.

KEYWORDS

Extensive-disease small cell lung cancer Anti-PD-L1 inhibitor Atezolizumab Lambert-Eaton myasthenic syndrome Anti-P/Q-type VGCC body

Received 10 Dec 2024 ／ Accepted 27 Jan 2025

AJRS, 14(3): 118-121, 2025

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Content

Abstract

Case Report

ABSTRACT

KEYWORDS