Lung Involvement in Rapidly Progressive Glomerulonephritis
Hiroyo Kourakata Isao Saito Kenichi Igarashi Eiichi Suzuki Masaaki Arakawa Fumitake Gejyo
Department of Internal Medicine (II), Niigata University School of Medicine, Asahi-machi-dori 1, Niigata 951-8510, Japan
The purpose of this study is to evaluate pulmonary involvement in rapidly progressive glomerulonephritis (RPGN). Of 71 patients in whom RPGN was diagnosed, 32 (45.1%) had pulmonary involvement: 12, alveolar hemorrhage (AH) (16.9%); 10, interstitial pneumonia (IP) (14.1%); four, chronic bronchial lesions (5.6%); two, consolidation (2.8%), and four, old inflammatory lesions (5.6%). Investigation of which organ of the twelve AH patients, the kidney or the lung, was the first to be involved, showed that the lung preceded in one patient, the kidney was first in three, and the lung and kidney occurred at the same time in the other eight. Of the ten IP patients, the lung preceded in eight, the kidney was ahead in two, and lung and kidney were simultaneous in one. Three patients had a history of pneumoconiosis, and two had acute progressive IP. Seventeen (45.9%) of 37 patients who tested positive for antineutrophil cytoplasmic autoantibodies (MPO-ANCA) had lung involvement, and three (30.0%) of the ten patients who tested negative for MPO-ANCA, PR3-ANCA and anti-GBM antibody also had lung involvement.
Rapidly progressive glomerulonephritis Interstitial pneumonia Alveolar hemorrhage Pulmonary involvement Anti-neutrophil cytoplasmic antibody
Received 平成12年7月11日
JJRS, 39(2): 104-109, 2001