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Article in Japanese
Abstract
Original Article
Clinical Characterization of Interleukin-8 in Patients with Idiopathic Pulmonary Fibrosis
Yoshitaka Totani1) Yuji Saitoh1) Hiroki Sakakibara1) Isamu Miyamori2) Takeshi Ishizaki3)
1)Division of Respirology & Allergology, Department of Internal Medicine, School of Medicine,
Fujita Health University, Kutsukake-Cho, Toyoake City, Aichi 470-1192, Japan
2)Third Department of Internal Medicine, and 3)Department of Fundamental Nursing,
Fukui Medical University, Matsuoka-Cho, Fukui 910-1193, Japan
ABSTRACT
The levels of interleukin-8 (IL-8) in the serum, bronchoalveolar fluid (BALF) and epithelial lining fluid (ELF) were measured in patients with idiopathic pulmonary fibrosis (IPF), in order to evaluate the clinical significance of IL-8. The serum levels were significantly higher in patients with active IPF (34.4± 11.9 pg/ml, n=8) than in those with stable IPF (mean: 14.6± 10.9 pg/ml, n=18), but neither correlated with the serum level of KL-6 or of SP-D, or with the intensity of chest Ga67-scintigraphy. There were no significant differences in BALF or ELF IL-8 levels between the active and stable IPF groups. These results suggest that the serum level of IL-8 is a useful marker for evaluating the disease activity in patients with IPF.
KEYWORDS
IL-8 Idiopathic pulmonary fibrosis Disease activity
Received 平成14年5月10日
JJRS, 40(11): 869-874, 2002
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