Paraneoplastic Neurologic Syndrome and Small-Cell Lung Cancer in a Patient Positive for Anti-Hu Antigen
Yoshiko Koyama Kouichi Miyashita Masaki Anzai Maiko Kadowaki Masakuni Fujita Shirou Mizuno Yoshitaka Totani Yoshiki Demura Shingo Ameshima Takeshi Ishizaki Isamu Miyamori
Department of Internal Medicine, Fukui Medical University, 23-3, Shimo-Aizuki, Matsuoka-cho, Yoshida-gun, Fukui 910-1193
We encountered a case of small-cell lung cancer with paraneoplastic neurologic syndrome in a 68-year old man. Progressive dysesthesia had developed in his hands and legs over a period of 4 months. Chest radiography and chest CT scanning on admission showed a mass in the hilum of the left lung. Anti-Hu antibody was found in his serum and the subsequent histopathological diagnosis by TBLB was small cell lung cancer. The patient underwent complete remission, in terms of tumor size, as a result of concurrent chemoradiotherapy (cisplatin, etoposid) and the dysesthesia in his legs was alleviated.
Anti-Hu antibody Small cell lung cancer Paraneoplastic neurologic syndrome
Received 平成14年6月12日
JJRS, 41(1): 35-38, 2003