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Article in Japanese
Abstract
Original Article
Reactivation of Epstein-Barr virus is involved in the pathogenesis of lymphomatoid granulomatosis
Hiroki Suzuki Hiroaki Takeda Hiroyuki Kishi Yutaka Machida Sinichirou Mikura Keitarou Watanabe
Department of Respiratory Medicine, Saiseikai Yamagata Saisei Hospital
ABSTRACT
Recent studies point to a role of Epstein-Barr virus in the pathogenesis of lymphomatoid granulomatosis. Little is however known about the association of the pathogenesis of the disease with Epstein-Barr virus reactivation. A 46-year-old man presented with fever and general malaise. He had been admitted with fever of unknown origin 10 years previously. Chest radiographs and CT scans showed multiple nodular shadows in both lung fields. PET/CT showed strong accumulation in lung nodules, femoral muscle, lumbar subcutaneous nodule. He died of rapidly progressive neurological lesions. The definitive diagnosis of lymphomatoid granulomatosis was made from histological findings of the surgical biopsy specimen and at autopsy. Elevation of early antigen-IgG titer in serum was shown in this case. This result suggests that reactivation of Epstein-Barr virus is involved in the development of the disease.
KEYWORDS
Lymphomatoid granulomatosis (LYG) Epstein-Barr virus (EBV) reactivation Early antigen-IgG (EA-IgG)
Received 平成17年11月4日
JJRS, 44(7): 492-498, 2006
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