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Abstract
Case Report
Unexplained pulmonary arterial hypertension in a patient with lung resection, treated with sildenafil and beraprost
Miho Shimokawa Fumio Sakamaki Takuya Aoki* Yurika Yogo Akinori Ebihara
Department of Medicine, Tokyo Saiseikai Central Hospital *Mito Red-Cross Hospital
ABSTRACT
A 70-year-old man with a past history of lung resection for early stage lung cancer was admitted to our hospital because of worsening exertional dyspnea. Right heart catheterization revealed severe pulmonary arterial hypertension (PAH) with pulmonary vascular resistance of 1671.64 dyne.sec.cm-5. The patient was treated with sildenafil added to an oral prostacyclin analog, beraprost, and long term oxygen therapy. His exertional dyspnea continued to improve until his sudden death following nasal bleeding. Autopsy revealed marked thickening of pulmonary arteriolar walls, but no recurrence of lung cancer, significant pulmonary embolism or pulmonary parenchymal disease. His PAH could not be explained by the mild airway obstruction or sleep apnea syndrome, and unrelated pulmonary vascular disease was suspected.
KEYWORDS
Pulmonary arterial hypertension Sildenafil Beraprost
Received 平成18年1月11日
JJRS, 44(11): 817-822, 2006
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