A case of drug-induced pneumonia caused by clopidogrel
Gakuya Tamagaki1) Haruhiko Matsushita2) Tomohiro Suzumura2) Tetsuya Watanabe3) Seiji Yamada2) Kazuto Hirata3)
1)Department of Internal Medicine, Ikuwakai Memorial Hospital 2)Department of Internal Medicine, Izumi City Hospital 3)Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University
A 65-year-old man, who had been given a diagnosis of angina pectoris, developed pneumonia 6 months after the initiation of clopidogrel to inhibit platelet aggregation. Chest radiography showed bilateral invasive shadows, and he was admitted to our hospital. He was asymptomatic, but his C-reactive protein and erythrocyte sedimentation rate were elevated. A lymphocyte stimulation test (DLST) with clopidogrel was positive, and bronchoalveolar lavage fluid showed an increase in lymphocytes and a decrease in the CD4+/CD8+ratio. We noticed no radiologic improvement a week after prednisolone therapy (30 mg/day) with clopidogrel as stated. However, the airspace consolidation had slightly reduced after clopidogrel was halted. We found a few cases of ticlopidine-induced pneumonia, in the literature, but we found no cases of pulmonary adverse events caused by clopidogrel. To the best of our knowledge this is the first case of clopidogrel-induced pneumonia.
Drug induced pneumonia Clopidogrel Drug lymphocyte stimulation test (DLST) Prednisolone
Received 平成21年10月16日
JJRS, 48(5): 404-408, 2010