一般社団法人日本呼吸器学会 公式サイト
日本呼吸器学会英文誌 Respiratory Investigation
日本呼吸器学会誌 増刊号 学術講演会プログラム 抄録集

Abstract

Full Text of PDF Full Text of PDF (587k)
Article in Japanese

Original Article

A retrospective clinical study about the serum Aspergillus precipitating antibody testing in our hospital

Yoichiro Andoa  Yasuhiko Kitasatob,c  Yoshiaki Taob  Kazuko Matsunagac  Shinji Iseb  Shohei Takatab  Midori Kubotaa  Tomoaki Hoshinoc  Masayuki Kawasakib  Hisamichi Aizawac 

aDepartment of Clinical Laboratory, National Hospital Organization Fukuoka-Higashi Medical Center
bDepartment of Respirology, National Hospital Organization Fukuoka-Higashi Medical Center
cDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine

ABSTRACT

The objective of our retrospective clinical study was to investigate the validity of serum Aspergillus precipitating antibody testing (using the Aspergillus immunodiffusion system [Microgen Bioproducts Ltd., UK]) to diagnose chronic pulmonary aspergillosis (CPA). We gathered records of patients who required this test in our hospital from February to December in 2009. We examined the number of precipitation arcs, diagnoses of the patients, and frequencies of "false-negative" cases in "positive-result" patients and of "false-positive" cases in "negative-result" patients. In 24 positive-result patients, most showing more than two precipitation arcs in the test were patients with CPA, but it was doubtful that some were false-positive. In 99 negative-result patients, 85 were thought to be nonaspergillosis, but 4 with CPA showed false-negative results of this test at the first inspection. For the serodiagnosis of CPA, this test showed the best results if the positive judgment criteria were set as more than two precipitation arcs, such as sensitivity of 78.9% and a specificity of 95.6%. We consider this test useful for the clinical diagnosis of CPA.

KEYWORDS

Aspergillus precipitating antibody  Pulmonary aspergillosis  Sensitivity  Specificity 

Received 28 Feb 2011 / Accepted 25 Aug 2011

AJRS, 1(1): 3-8, 2012

Google Scholar