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日本呼吸器学会英文誌 Respiratory Investigation
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Abstract

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Article in Japanese

Case Report

A case of cellular bronchiolitis with primary Sjögren syndrome

Kazue Saitoa  Yoshinori Taninoa  Suguru Satoa  Kazuhiro Tasakib  Akira Hebisawac  Mitsuru Munakataa 

aDepartment of Pulmonary Medicine, School of Medicine, Fukushima Medical University
bDepartment of Pathology, Fukushima Medical University Hospital
cDivision of Clinical Laboratory, National Hospital Organization Tokyo National Hospital

ABSTRACT

A 67-year-old woman was referred to our hospital because of progressive productive cough, dyspnea on exertion, and abnormal chest shadows. She had been diagnosed as diffuse panbronchiolitis and has been treated with macrolides with no improvement. Chest computed tomography (CT) revealed bilateral diffuse centrilobular nodules, consolidation, and bronchiectasis. The diagnosis of primary Sjögren syndrome was made by xerostomia, positive serum SS-B antibody, and positive Schirmer test without symptoms, which suggest other collagen vascular diseases. Lung biopsy using video-associated thoracoscopy revealed transmural cellular infiltrate of small round cells around the entire circumference of bronchioles, and a pathological diagnosis of cellular bronchiolitis was made. Her symptoms and small nodular shadows on CT were improved after a 3-month treatment of prednisolone. We should take cellular bronchiolitis into account as one of the pulmonary manifestations of primary Sjögren syndrome because the bronchiolar disorder may be improved by steroid therapy.

KEYWORDS

Primary Sjögren syndrome  Cellular bronchiolitis  IgG4-related lung disease 

Received 9 Feb 2011 / Accepted 20 Jan 2012

AJRS, 1(4): 304-310, 2012

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