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Abstract

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Article in Japanese

Case Report

A case of small-cell lung cancer associated with paraneoplastic opsoclonus-myoclonus syndrome that developed during chemotherapy

Hiroko Fukata  Koichi Maekawa  Yumiko Ikegami 

Department of Respiratory Medicine, Ijinkai Takeda General Hospital

ABSTRACT

A 66-year-old man was diagnosed with small-cell lung cancer (SCLC; cT1aN2M1a, stage IV, extensive disease) in October 2010. He showed a partial radiological response with first-line chemotherapy (cisplatin and etoposide). The mediastinal lymph node became enlarged in May 2011, and second-line chemotherapy with nogitecan hydrochloride was administered. After 1 cycle of chemotherapy, the size of the lymph node reduced, but the patient experienced rapidly progressive dizziness, opsoclonus, myoclonus, and dysarthria. He was diagnosed with paraneoplastic opsoclonus-myoclonus syndrome (POMS) because of the lack of significant findings after blood examinations, cerebrospinal fluid test, brain magnetic resonance imaging, and electroencephalography. Regardless of steroid therapy, the neurologic symptoms did not improve. In fact, the patient's symptoms worsened, and he exhibited disturbance of consciousness; he died in October 2011. POMS has been reported to occur as a paraneoplastic neurological syndrome in SCLC patients, but it develops before the diagnosis of tumor in most cases. We have reported here a rare case of SCLC associated with POMS that developed during chemotherapy.

KEYWORDS

Small cell lung cancer  Paraneoplastic neurological syndrome  Paraneoplastic opsoclonus-myoclonus syndrome 

Received 23 Feb 2012 / Accepted 31 May 2012

AJRS, 2(1): 29-33, 2013

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