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Abstract

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Article in Japanese

Case Report

Drug-induced pneumonia by oral intake of combined chondroitin and hyaluronic acid supplement

Morihiro Tajiri  Yusuke Okayama  Yoshiko Naito  Tomotaka Kawayama  Tomoaki Hoshino 

Division of Respirology, Neurology, and Rheumatology, Department of Medicine Kurume University School of Medicine

ABSTRACT

A 74-year-old man who had been suffering from dry cough and shortness of breath for 4 months after regular use of the oral chondroitin and hyaluronic acid supplement was admitted to our hospital. Chest radiographs and computed tomograms revealed interstitial infiltrations and peribronchial opacities with bronchiectasis in the bilateral lung fields. Total cell counts, percentage of lymphocytes, and the CD4/CD8 ratio in the bronchoalveolar lavage fluid were 2.5×105/ml, 55.2%, and 0.58, respectively. Pathological examination of lung tissues obtained by video-assisted thoracic surgery demonstrated nonspecific interstitial pneumonia and organized pneumonia with proliferations of eosinophils and type II pneumocyte cell hyperplasia. The symptoms and lung abnormalities associated with drug-induced pneumonia were improved immediately without systemic corticosteroid therapy after the oral supplements were suspected to be responsible and were subsequently withdrawn. To our knowledge, this is the first reported case of pneumonia induced by oral intake of chondroitin and hyaluronic acid supplement.

KEYWORDS

Drug-induced pneumonia  Oral supplement  Chondroitin  Hyaluronic acid 

Received 16 Oct 2012 / Accepted 17 Jan 2013

AJRS, 2(4): 395-400, 2013

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