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Abstract

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Article in Japanese

Case Report

A case of anterior mediastinal leiomyosarcoma with multiple lung metastases and bone metastasis treated by chemotherapy

Kentaro Onoa  Tomoshi Takedaa  Mai Fujinamia  Koki Fukudaa  Yumi Katoa  Ryuichi Saitoa  Naoki Magonoa  Tetsuya Uedaa  Kenshi Bandoa  Koichiro Iwanagab  Shinsaku Uedab  Yoshinori Hasegawaa 

aDepartment of Respiratory Medicine, Osaka Saiseikai Nakatsu Hospital
bDepartment of Thoracic Surgery, Osaka Saiseikai Nakatsu Hospital

ABSTRACT

The patient was a 63-year-old woman who sought medical care for her chief complaint of a cough. Chest CT scans revealed an 82 mm×47 mm tumor in the anterior mediastinum accompanied by bilateral multiple lung nodules. A diagnosis of leiomyosarcoma was reached for a nodule in the lingular segment, which was biopsied using thoracoscopy. We made a diagnosis of anterior mediastinal leiomyosarcoma with multiple metastases to the lung, since other primary lesions could be ruled out on the basis of FDG-PET. Treatment of stage IV soft-tissue sarcoma has not been standardized, and few reports are available concerning the efficacy of chemotherapy for advanced mediastinal leiomyosarcoma. This case was therefore treated with 8 courses of doxorubicin, based on past reports concerning the management of soft-tissue sarcoma. As a result, the patient is still alive after 18 months of doxorubicin therapy with an 11-month period of nonprogression.

KEYWORDS

Soft tissue sarcoma  Leiomyosarcoma  Anterior mediastinum  Multiple pulmonary metastases  Chemotherapy 

Received 17 Jan 2013 / Accepted 4 Jul 2013

AJRS, 2(6): 742-745, 2013

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