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Abstract

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Article in Japanese

Case Report

A case of multiple bone and brain metastasis in primary pulmonary adenocarcinoma treated with zoledronic acid

Takeo Inoue  Masamichi Mineshita  Hiromi Muraoka  Mariko Okamoto  Teppei Inoue  Teruomi Miyazawa 

Division of Respiratory and Infectious Disease, Department of Internal Medicine, St. Marianna University School of Medicine

ABSTRACT

Bone metastases occur in 30-40% of patients with lung cancer. Recent studies have demonstrated positive antitumor effects with zoledronic acid (ZOL). However, whether ZOL exerts antitumor activity for lung cancers remains unclear. An 87 year-old male referred to our hospital for investigation of an abnormal shadow on chest X-ray. Chest CT revealed a 74×46 mm mass at the left upper lobe (S1+2), and an osteolytic change in the thoracic vertebra. PET showed accumulations at the spine, left clavicle, left multiple ribs, right scapula, and right humerus. This patient was diagnosed with pulmonary adenocarcinoma having multiple metastases of the brain and bone by sputum cytology. He received only ZOL because of his advanced age and performance status. A chest X-ray was performed after four administrations of ZOL, which revealed that the mass shadow at the left upper lung field was remarkably reduced. Chest CT revealed that the size of the mass had decreased (66×38 mm), and an improvement in QOL was noted after ZOL monotherapy. We believe this case may have demonstrated possible antitumor effects of ZOL for non small cell lung cancer.

KEYWORDS

Bone metastasis  Zoledronic acid  Non small cell lung cancer  Anti-tumor effect 

Received 27 Aug 2013 / Accepted 28 Nov 2013

AJRS, 3(2): 276-280, 2014

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