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Abstract

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Article in Japanese

Case Report

A case of bronchiolitis obliterans diagnosed after chemotherapy for malignant lymphoma

Tomoe Nishiharaa  Katsuyuki Katahirab  Hiroko Nogamib  Naozumi Hashimotoc  Tomoaki Iwanagab 

aDepartment of Psychosomatic Medicine, National Hospital Organization Fukuoka National Hospital
bDepartment of Respiratory Medicine, National Hospital Organization Fukuoka National Hospital
cDepartment of Respiratory Medicine, Graduate School of Medical Sciences, Nagoya University

ABSTRACT

Bronchiolitis obliterans (BO) is a common sequela of bone marrow, lung, and heart-lung transplantation, but rarely occurs as a complication of certain pulmonary infections, adverse drug reactions, toxic inhalation, or autoimmune disorders (nontransplant-related BO). We describe a 63-year-old female patient who developed progressive obstructive ventilatory impairment and respiratory failure within 5 years after chemotherapy [R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, predonisolone)] for non-Hodgkin's lymphoma. She appeared as a nontransplant patient, but her clinical history and mosaic-perfusion pattern monitored by HRCT suggested the possibility of BO. We conducted open biopsy (video-assisted thoracic surgery) and detected constrictive BO features in the lung tissue: obstruction of the bronchioles because of an ingrowth of the fibroid tissue. She is currently being treated with home-oxygen therapy and noninvasive positive pressure ventilation.

KEYWORDS

Bronchiolitis obliterans (BO)  Malignant lymphoma  Obstructive ventilatory impairment  Non-transplant-related 

Received 29 Aug 2013 / Accepted 2 Dec 2013

AJRS, 3(2): 281-286, 2014

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