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Article in Japanese
Abstract
Case Report
A case of lung adenocarcinoma that transformed to small cell carcinoma
Haruna Masaki Satoru Ishii Yuichiro Takeda Sho Watanabe Masayuki Hojo Haruhito Sugiyama
Department of Respiratory Medicine, National Center for Global Health and Medicine
ABSTRACT
A 59-year-old woman, who had been diagnosed with lung adenocarcinoma T3N2M1b Stage IV with EGFR mutation (Exon 19 E746-A750del) and undergone chemotherapies (cisplatin+pemetrexed→erlotinib), was admitted to our hospital with a complaint of abdominal distention. The primary lesion was well controlled; however, the metastases to abdominal lymph nodes were developed. Lymph-node biopsies showed positive staining for both TTF-1 and synaptophysin, suggesting a transformation from adenocarcinoma to small cell lung carcinoma. Chemotherapeutic agents for small cell lung carcinoma tended to decrease the size of lymph nodes. Here we report a transformation case of lung adenocarcinoma to small cell carcinoma, with a review of relevant literatures.
KEYWORDS
EGFR-TKI Transformation to SCLC Resistance-gaining mechanism
Received 18 Sep 2013 ／ Accepted 18 Feb 2014
AJRS, 3(4): 541-547, 2014
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