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Article in Japanese
Abstract
Case Report
A case of drug-induced pneumonitis caused by vildagliptin
Takehiro Yajima Daisuke Jingu Makoto Shoji Takayuki Igarashi Hiroshi Watanabe Hiroshi Takahashi
Department of Respiratory Medicine, Saka General Hospital
ABSTRACT
An 85-year-man had been prescribed vildagliptin to treat type 2 diabetes mellitus from 19 March 2013 to 21 June 2013. Because of renal dysfunction, vildagliptin was changed to linagliptin from 21 June 2013. He had developed dyspnea, and his computed tomography scan showed ground-glass opacity on 26 June. The lymphocyte fractionation of bronchoalveolar lavage fluid elevated at 62%. After administration of corticosteroids, he recovered smoothly. A drug lymphocyte stimulation test for vildagliptin was positive. Recently, prescriptions of the dipeptidyl peptidase 4 (DPP-4) inhibitors have increased. We should maintain attention for lung injury.
KEYWORDS
Drug-induced pneumonitis Vildagliptin Linagliptin Dipeptidyl peptidase 4 (DPP-4) inhibitor Diabetes mellitus
Received 22 Aug 2014 ／ Accepted 15 Dec 2014
AJRS, 4(2): 176-180, 2015
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