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Article in Japanese
Abstract
Case Report
A case of acute eosinophilic pneumonia probably induced by daptomycin
Kazunori Tsujimotoa Hiroyuki Tokib Yoshitaka Ogawac Hiroyuki Yamatod Yoshikazu Miyakeb Ken Kodamae
aDepartment of Infection Control and Prevention, Yao Municipal Hospital
bDepartment of Plastic and Reconstructive Surgery, Yao Municipal Hospital
cDepartment of Diabetes Mellitus and Endocrinology, Yao Municipal Hospital
dDepartment of Surgery, Yao Municipal Hospital
eDepartment of Thoracic Surgery, Yao Municipal Hospital
ABSTRACT
While a 62-year-old man with infectious diabetic foot ulcers was treated with levofloxacin and daptomycin, he suffered from acute eosinophilic pneumonia. He was rapidly improved by the discontinuation of antimicrobials one after another and treatment with prednisolone. On the basis of the clinical course, we considered this case to be acute eosinophilic pneumonia, probably induced by daptomycin. The reports of acute eosinophilic pneumonia induced by daptomycin are very rarely found in Japan, but there are some reports of this disease in other countries. An increase in this disease is expected in the future in the country as use frequency of daptomycin increases for MRSA infections, especially, diabetic foot infection, osteomyelitis and from alien substances. Therefore more attention should be paid to the adverse effects of daptomycin.
KEYWORDS
Daptomycin Levofloxacin Drug-induced lung disease Acute eosinophilic pneumonia (AEP) Allergy
Received 5 Feb 2015 ／ Accepted 31 Jul 2015
AJRS, 4(6): 468-472, 2015
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