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日本呼吸器学会英文誌 Respiratory Investigation
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Abstract

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Article in Japanese

Case Report

Mycobacterium xenopi lung infection in a healthy young person suspected to be lung cancer: Case report

Satoshi Tetsumoto  Yoshito Kusakabe  Naotoshi Tsuruta  Takashi Niju  Toshiyuki Ikeda 

Department of Respiratory Medicine, Nishinomiya Municipal Central Hospital

ABSTRACT

The following describes the case of a healthy 29-year-old man whose chest radiography at the time of medical examination revealed a solitary pulmonary nodule without a tree-in-bud pattern and a cavity in the upper right lung. Histopathological findings of samples obtained by bronchoscopic biopsy showed nonspecific inflammation, and bronchial lavage was negative for acid-fast bacilli and bacterial culture. Because the nodule had a high FDG uptake on PET/CT imaging, it was suspected to be lung cancer. For a definitive diagnosis, partial resection of the right upper lobe was performed by video-assisted thoracoscopy. Histopathological examination of tissue samples obtained from the right upper lung revealed epithelioid granuloma, and culture from the samples grew Mycobacterium xenopi. We then performed DNA sequence analysis to distinguish between M. xenopi and Mycobacterium heckeshornense. The analysis demonstrated that the acid-fast bacilli cultured from the samples were M. xenopi. A lung infection by M. xenopi was diagnosed in this patient. Although the patient received no chemotherapy for M. xenopi infection after surgery, no recurrence has been observed.

KEYWORDS

Mycobacterium xenopi  Non-tuberculous mycobacteriosis  FDG-PET  DNA sequence analysis  DNA-DNA hybridization 

Received 12 Jun 2015 / Accepted 10 Sep 2015

AJRS, 5(1): 28-31, 2016

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