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Abstract

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Article in Japanese

Case Report

Imatinib mesylate-induced organizing pneumonia with disease progression after discontinuation of treatment, diagnosed by surgical lung biopsy

Akifumi Uchidaa  Masuki Yamamotoa  Midori Matsuyamaa  Shingo Kubotaa  Kazuhito Hatanakab  Hiromasa Inouea 

aDepartment of Pulmonary Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University
bDepartment of Molecular and Cellular Pathology, Graduate School of Medical and Dental Sciences, Kagoshima University

ABSTRACT

Upon 273 days after starting imatinib mesylate therapy, a 73-year-old woman with gastrointestinal stromal tumor without any symptoms presented with an abnormality on computed tomography. The abnormality, which was a consolidation in the peribronchovascular bundle, progressively developed after she discontinued imatinib mesylate. She presented with progressive cough and dyspnea. A histopathological examination of the surgical lung biopsy specimen revealed polypoid plugs of organizing connective tissue within the alveolar spaces and lymphocytic infiltration into the alveolar wall. She was therefore diagnosed as having imatinib mesylate-induced organizing pneumonia. She was treated by corticosteroid therapy. Her symptoms improved and the consolidation in the peribronchovascular bundle was resolved. Imatinib mesylate-induced lung disease presents as various abnormalities. The progression of pneumonitis rarely occurs in patients after discontinuing imatinib mesylate treatment. The histopathological analysis of the surgical lung biopsy was useful for definitive diagnosis and predicting the prognosis and treatment response in this patient.

KEYWORDS

Imatinib mesylate  Drug-induced lung disease  Organizing pneumonia  Surgical lung biopsy 

Received 10 Dec 2015 / Accepted 22 Feb 2016

AJRS, 5(4): 208-212, 2016

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