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Abstract
Case Report
A case of pulmonary adenocarcinoma with concomitant EGFR gene mutation and EML4-ALK fusion gene
Yuya Inadaa Kazuhiro Yanagiharab,c Kohei Iwasakia Shinya Yoshidaa Utae Katsushimab,c Tomoyoshi Itoha
aDepartment of Respiratory Medicine, Kansai Electric Power Hospital
bDepartment of Medical Oncology, Kansai Electric Power Hospital
cDivision of Clinical Oncology, Kansai Electric Power Medical Research Institute
ABSTRACT
A 66-year-old man with dry cough and dyspnea, whose computed tomography indicated bronchopneumonia and tumor in the right lower lobe, was referred to our hospital. He was diagnosed with advanced lung cancer (cT4N3M1a) with EGFR mutation (exon 19 deletion) and treated with afatinib. But 9 weeks later he was diagnosed with progressive disease. In the same specimen at the diagnosis EML4-ALK fusion gene was also found. He was treated with alectinib as secondary regimen and got stable disease for 9 months.
KEYWORDS
Non-small cell lung cancer Epidermal growth factor receptor Echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase Afatinib Alectinib
Received 16 Mar 2017 ／ Accepted 26 Jun 2017
AJRS, 6(5): 327-331, 2017
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