一般社団法人日本呼吸器学会 公式サイト
日本呼吸器学会英文誌 Respiratory Investigation
日本呼吸器学会誌 増刊号 学術講演会プログラム 抄録集 検索用
日本呼吸器学会誌 増刊号 学術講演会プログラム 抄録集 全文PDF

Abstract

Full Text of PDF Full Text of PDF (469k)
Article in Japanese

Case Report

A case of Wernicke’s encephalopathy that developed during treatment for lung cancer

Kenji Morimotoa  Mai Komorib  Koji Datea  Hidehiko Kawanoa 

aDepartment of Pulmonary Medicine, Kyoto Chubu Medical Center
bDepartment of General Internal Medicine, Kyoto Chubu Medical Center

ABSTRACT

An 82-year-old woman was diagnosed with epidermal growth factor re-ceptor (EGFR)-mutation-positive lung adenocarcinoma Stage IV and was treated with gefitinib. She experienced disorientation, cerebellar ataxia, and horizontal nystagmus during treatment. Magnetic resonance imaging (MRI) of the brain with fluid-attenuated inversion recovery sequence showed an area of high-signal intensity in the periventricular-periaqueductal gray region of the third ventricle, and Wernicke’s encephalopathy was diagnosed. Symptoms promptly improved on vitamin B1 ad-ministration. Malignant tumors are a risk factor for the development of Wernicke’s encephalopathy, but reports in lung cancer patients are rare. This could be due to inaccurate diagnosis.

KEYWORDS

Lung cancer  Wernicke’s encephalopathy  Vitamin B1 deficiency 

Received 24 Mar 2017 / Accepted 7 Aug 2017

AJRS, 6(6): 450-453, 2017

Google Scholar