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Abstract

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Article in Japanese

Case Report

Primary lung adenocarcinoma associated with IgG4-related lung disease

Koji Tokudaa,b  Takakiyo Nakayab  Masayuki Nakayamab  Masashi Bandob  Yukihiko Sugiyamab  Hirokazu Hagiwarab 

aRespiratory and COPD Center, Japan Association for Development of Community Medicine Nerima Hikarigaoka Hospital
bDivision of Pulmonary Medicine, Department of Medicine, Jichi Medical University

ABSTRACT

IgG4-related lung disease was diagnosed in a 71-year-old man, and resolved spontaneously. However, five years later, a chest contrast-enhanced computed tomography (CT) scan showed bilateral lung nodules, and hilar and mediastinal lymphadenopathy. His serum IgG4 levels were elevated. Based on the diagnosis of a recurrence of IgG4-related lung disease, systemic corticosteroid therapy was introduced. Chest radiologic findings improved and serum IgG4 levels declined. Subsequently, however, a right hilar mass and mediastinal lymphadenopathy appeared on chest contrast-enhanced CT scan. A transbronchial biopsy specimen obtained from the right main bronchus revealed primary lung adenocarcinoma. Physicians should be aware that primary lung cancer might be associated with IgG4-related lung disease.

KEYWORDS

IgG4-related lung disease  Primary lung adenocarcinoma  Transbronchial biopsy 

Received 21 Jul 2017 / Accepted 1 Nov 2017

AJRS, 7(1): 20-24, 2018

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