A 73-year-old female with atopic asthma, who was prescribed daily administration of an inhaled and oral short-acting β₂ agonist (SABA), had a sudden-onset severe asthma exacerbation. Her condition deteriorated to include wheezing and dyspnea, and she was taken by ambulance to a nearby hospital. SABA nebulizer was given, epinephrine (0.2mg) was subcutaneously injected twice, and intravenous hydrocortisone was also administered. Following admission, dyspnea worsened and an electrocardiogram revealed negative T waves in I, II, aVf, and V₃–V₆. Furthermore, echocardiography demonstrated apical dyskinesia, and creatinine kinase levels were found to be mildly elevated. After treatment for the asthma attack, the patient was diagnosed with Takotsubo cardiomyopathy. In the present case, we speculate that Takotsubo cardiomyopathy was triggered by a SABA overdose and the subcutaneous injection of epinephrine, as well as by the severe asthma attack itself. Physicians should keep in mind that Takotsubo cardiomyopathy is a possible complication of an asthma attack and the associated treatment.