一般社団法人日本呼吸器学会 公式サイト
日本呼吸器学会英文誌 Respiratory Investigation
日本呼吸器学会誌 増刊号 学術講演会プログラム 抄録集 検索用
日本呼吸器学会誌 増刊号 学術講演会プログラム 抄録集 全文PDF

Abstract

Full Text of PDF Full Text of PDF (543k)
Article in Japanese

Case Report

A case of interstitial pneumonia accompanying ulcerative colitis that was barely distinguishable from drug-induced lung injury

Naomi Saito  Mayuka Yamane  Yojiro Onari 

Department of Respiratory Medicine, Mazda Hospital, Mazda Motor Corporation

ABSTRACT

Ulcerative colitis (UC) can be complicated by extraintestinal manifestations; for example, arthritis, pyoderma gangrenosum, and uveitis. On the other hand, several cases of interstitial pneumonia accompanying UC have been reported. Case: A 75-year-old man with a history of UC who had been treated with mesalazine since 20XX-3. In February 20XX, he was hospitalized for 2 months because of exertional dyspnea. A chest computed tomography (CT) scan revealed diffuse consolidation in both lungs and a blood test showed elevated KL-6 serum levels (844U/mL). We suspected interstitial pneumonia and performed a bronchoscopy. Bronchoalveolar lavage fluid (BALF) analysis showed a high lymphocyte count (44%), and bacterial infection was ruled out. We diagnosed him with a drug-induced lung injury due to mesalazine, and discontinued mesalazine. The patient experienced a favorable response to steroid therapy. However, while tapering the steroid, lung consolidation occurred again, and we evaluated the use of the steroid. In addition, lung consolidation had not recurred after an incidental resumption of mesalazine. From this clinical course, we confirmed interstitial pneumonia accompanying UC rather than a drug-induced lung injury. We report a case of interstitial pneumonia accompanying UC that was barely distinguishable from drug-induced lung injury caused by mesalazine.

KEYWORDS

Interstitial pneumonia accompanying ulcerative colitis  Drug-induced lung injury  Mesalazine 

Received 17 Mar 2018 / Accepted 12 Jul 2018

AJRS, 7(6): 374-378, 2018

Google Scholar