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Abstract

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Article in Japanese

Case Report

A case of pulmonary Langerhans cell histiocytosis diagnosed by cell block from bronchoalveolar lavage fluid

Kazuki Hirata  Masaki Sakurai  Naoyuki Shiraishi Takashi Morioka  Masanobu Arai  Hideyuki Aono 

Department of Internal Medicine, Saiseikai Chuwa Hospital

ABSTRACT

A 62-year-old man who had smoked 15 cigarettes per day for 42 years was referred to our hospital because of non-productive cough and an abnormal chest shadow. Chest computed tomography (CT) scan revealed multiple micronodules and small centrilobular nodular shadows in both lung fields. We performed bronchoalveolar lavage (BAL) into the right B5b and fiberoptic transbronchial lung biopsy (TBLB) of the right B4, B8, and B9. Although the TBLB specimens showed non-specific inflammation, histopathological findings of the cell block obtained by BAL revealed 8.0% of the BAL cells to be positive for CD1a immunocytochemically. From these observations, we finally diagnosed him with pulmonary Langerhans cell histiocytosis (PLCH), and most of the shadow on chest CT scan had disappeared 4 weeks after cessation of smoking. We report a case of PLCH successfully diagnosed using cell block from the BAL.

KEYWORDS

Pulmonary Langerhans cell histiocytosis (PLCH)  Bronchoalveolar lavage (BAL)  Transbronchial lung biopsy (TBLB)  Cell block 

Received 30 May 2018 / Accepted 31 Jul 2018

AJRS, 7(6): 384-388, 2018

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