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Article in Japanese
Abstract
Case Report
A case of lung cancer in the young with EGFR T790M mutation confirmed by re-biopsy of breast metastasis
Atsuko Hirabae Noriyuki Suzaki Takuya Nagata Masaomi Marukawa
Department of Internal Medicine, Kagawa Rosai Hospital
ABSTRACT
The patient was a 35-year-old female who visited a local doctor because of chronic cough. She had a massive right pleural effusion, and was referred to our hospital. Contrast-enhanced computed tomography showed shadowing with indistinct margins in the right breast and swelling in the right axillary lymph node. Pleural cytology and core needle biopsy of the breast confirmed EGFR gene mutation-positive lung adenocarcinoma with metastasis to the breast. First-line treatment with gefitinib was performed followed by second-line treatment with cytotoxic anticancer drugs. Then, re-biopsy of the breast metastasis was conducted which confirmed the T790M mutation. Third-line treatment with osimertinib was effective. The patient’s general condition remained good.
KEYWORDS
Breast metastasis Re-biopsy T790M mutation Lung cancer in the young
Received 14 Jun 2018 ／ Accepted 25 Oct 2018
AJRS, 8(1): 21-25, 2019
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