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Article in Japanese
Abstract
Case Report
A case of lung cancer with pleural dissemination showing exacerbated pleurisy symptoms following pembrolizumab administration
Hideto Oshita Noriaki Ito Misato Senoo Yutaro Yamamoto Kohei Kawasaki Ken Okusaki
Department of Internal Medicine, Mihara Medical Association Hospital
ABSTRACT
A 77-year-old man with pleural dissemination due to squamous cell lung carcinoma developed right-sided chest pain and fever following pembrolizumab administration. Narcotic analgesics and anti-inflammatory drugs were effective for symptomatic relief. Computed tomography revealed the temporary progression of multiple pleural nodules, followed by pronounced shrinkage. The clinical course of our case was consistent with pseudoprogression. Chest pain and marked inflammation were attributed to an immune response to pleural lesions. As immune checkpoint inhibitors could exhibit a non-specific response pattern, it is necessary to carefully determine the clinical effects.
KEYWORDS
Immune checkpoint inhibitor (ICI) Pleural dissemination Pseudoprogression
Received 10 Jan 2019 ／ Accepted 19 Feb 2019
AJRS, 8(3): 193-197, 2019
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