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Abstract

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Article in Japanese

Case Report

Chemotherapy improves skin lesions caused by thymoma-associated multiorgan autoimmunity

Yuki Fukushiroa  Yusuke Takayamaa  Shohei Mishimaa  Ken Masudaa  Hiroyasu Shodaa  Yasuo Iwamotob 

aDepartment of Respiratory Medicine, Hiroshima City Hiroshima Citizens Hospital
bDepartment of Oncology, Hiroshima City Hiroshima Citizens Hospital

ABSTRACT

A 74-year-old female was admitted to our hospital with rash that worsened as the thymoma progressed. A skin biopsy was performed, and histopathological examination revealed a graft-versus-host disease (GVHD)-like reaction. She was diagnosed with thymoma-associated multiorgan autoimmunity (TAMA). TAMA is a rare disease that has been recently reported in the literature and is a paraneoplastic syndrome associated with thymoma. This disease has a poor prognosis, and there is no established treatment at present. We describe a case of TAMA with skin lesions that was successfully treated with chemotherapy.

KEYWORDS

Thymoma  Paraneoplastic syndrome  Graft-versus-host disease (GVHD)  Psoriasiform rash 

Received 3 Mar 2020 / Accepted 13 May 2020

AJRS, 9(5): 325-329, 2020

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