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日本呼吸器学会英文誌 Respiratory Investigation
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Abstract

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Article in Japanese

Case Report

A case of pulmonary epithelioid hemangioendothelioma with a solitary nodular shadow diagnosed by transbronchial lung biopsy

Mizuho Tosaka  Tatsuhiko Kamoshida  Akifumi Mochizuki  Mayumi Fujii  Yoshikazu Tsukada 

Department of Pulmonary Medicine, Soka Municipal Hospital

ABSTRACT

A 56-year-old man was referred to our hospital for examination of a small pulmonary nodule revealed by chest X-ray. Contrast-enhanced chest computed tomography (CT) confirmed a solitary nodule of approximately 15mm in diameter in segment 8 of the left lung. 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) showed no FDG uptake by the nodule. Transbronchial lung biopsy (TBLB) was performed to exclude the possibility of primary lung cancer. Pathological findings revealed a central hyalinized matrix and proliferation of epithelium-like cells. Immunohistochemical staining showed that tumor cells were positive for CD31 and CD34. Pulmonary epithelioid hemangioendothelioma (PEH) was diagnosed based on these findings. Clinical manifestation of PEH is variable; typically, patients are asymptomatic, and PEH is detected on routine chest radiographs as multiple small nodules in bilateral lungs. Diagnosis of PEH usually requires a surgical lung biopsy. Herein, we describe a rare case of PEH with a unilateral nodule that was diagnosed by TBLB.

KEYWORDS

Pulmonary epithelioid hemangioendothelioma (PEH)  Transbronchial lung biopsy (TBLB)  Solitary nodular shadow  18F-fluorodeoxyglucose positron emission tomography 

Received 25 Mar 2020 / Accepted 25 Jun 2020

AJRS, 9(5): 335-339, 2020

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