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Abstract

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Article in Japanese

Case Report

A case of lung adenocarcinoma with signet ring cell carcinoma features diagnosed by thoracoscopic lung resection

Daisuke Naritaa  Eisaku Miyauchia  Ryoko Saitob  Shunsuke Ebac  Yoshinori Okadac  Masakazu Ichinosea 

aDepartment of Respiratory Medicine, Tohoku University Graduate School of Medicine
bDepartment of Anatomic Pathology, Tohoku University Graduate School of Medicine
cDepartment of Thoracic Surgery, Tohoku University Graduate School of Medicine

ABSTRACT

A 70-year-old woman was referred to our hospital due to a mass lesion detected in the left lower lobe of the lung field on chest computed tomography (CT). A bronchoscopy was performed, and she was diagnosed with lung adenocarcinoma, cT2bN0M0 Stage IIA, and partial thoracoscopic lung resection of the left lower lobe was performed due to extensive pleural dissemination in the lower left lobe. Histological examination of the resected tumor showed that clear columnar cells with abundant mucus had proliferated to form a small gland duct. The tumor cells yielded CK7 (+), CK20 (-), CDX2 (+), TTF-1 (-), and Napsin A (-) on immunohistological examination. Upper and lower endoscopy revealed no gastrointestinal tract tumors. Therefore, we finally diagnosed lung adenocarcinoma with a signet ring cell carcinoma-like morphology. She received carboplatin + pemetrexed + pembrolizumab combination therapy as a first-line treatment.

KEYWORDS

Lung cancer  Signet ring cell carcinoma 

Received 25 Feb 2020 / Accepted 3 Jul 2020

AJRS, 9(5): 345-349, 2020

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