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Article in Japanese
Abstract
Case Report
A case of asymptomatic pulmonary lymphomatoid granulomatosis
Yoshihisa Horia Makoto Kurokawaa Fumitoshi Yoshimine aKazumasa Ohashib Ryu Itob Toshinori Takadab
aDepartment of Respiratory Medicine, Niigata Prefectural Tokamachi Hospital
b Department of Respiratory Medicine and Infectious Diseases, Uonuma Kikan Hospital
ABSTRACT
A 66-year-old woman visited us with a chest X-ray abnormality at a medical checkup four years ago. Chest CT demonstrated multiple infiltrates and thickened interlobular walls. She also had hypergammaglobulinemia. Although she experienced no subjective symptoms, her lung lesions gradually worsened. In bronchoalveolar lavage, plasma cells accounted for 69% of the total cells. On surgical lung biopsy, a proliferation of lymphocytes with follicle-like structures, disruption of alveolar architecture, and lymphocyte infiltration into the vessel wall were observed. We also spotted EBER-1 positive lymphocytes between the follicles by immunostaining, which led to her diagnosis of pulmonary lymphomatoid granulomatosis. The patient has shown no exacerbation for about one year after diagnosis without specific treatment.
KEYWORDS
Pulmonary lymphomatoid granulomatosis Hypergammaglobulinemia Epstein-Barr virus (EBV)
Received 14 Apr 2020 ／ Accepted 16 Jun 2020
AJRS, 9(5): 365-369, 2020
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