一般社団法人日本呼吸器学会 公式サイト
日本呼吸器学会英文誌 Respiratory Investigation
日本呼吸器学会誌 増刊号 学術講演会プログラム 抄録集

Abstract

Full Text of PDF Full Text of PDF (550k)  required ID / password
Article in Japanese

Case Report

A case of asymptomatic pulmonary lymphomatoid granulomatosis

Yoshihisa Horia  Makoto Kurokawaa  Fumitoshi Yoshimine  aKazumasa Ohashib  Ryu Itob  Toshinori Takadab 

aDepartment of Respiratory Medicine, Niigata Prefectural Tokamachi Hospital
b Department of Respiratory Medicine and Infectious Diseases, Uonuma Kikan Hospital

ABSTRACT

A 66-year-old woman visited us with a chest X-ray abnormality at a medical checkup four years ago. Chest CT demonstrated multiple infiltrates and thickened interlobular walls. She also had hypergammaglobulinemia. Although she experienced no subjective symptoms, her lung lesions gradually worsened. In bronchoalveolar lavage, plasma cells accounted for 69% of the total cells. On surgical lung biopsy, a proliferation of lymphocytes with follicle-like structures, disruption of alveolar architecture, and lymphocyte infiltration into the vessel wall were observed. We also spotted EBER-1 positive lymphocytes between the follicles by immunostaining, which led to her diagnosis of pulmonary lymphomatoid granulomatosis. The patient has shown no exacerbation for about one year after diagnosis without specific treatment.

KEYWORDS

Pulmonary lymphomatoid granulomatosis  Hypergammaglobulinemia  Epstein-Barr virus (EBV) 

Received 14 Apr 2020 / Accepted 16 Jun 2020

AJRS, 9(5): 365-369, 2020

Google Scholar