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日本呼吸器学会英文誌 Respiratory Investigation
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Abstract

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Article in Japanese

Case Report

A case of GATA2 deficiency with Mycobacterium kansasii infection

Kohei Iwasakia  Tomoyoshi Itoha  Masato Shinokia  Kanako Tamuraa  Yuya Inadaa  Hidekazu Tachib 

aDepartment of Respiratory Medicine, Kansai Electric Power Hospital
bDepartment of Thoracic Surgery, Kansai Electric Power Hospital

ABSTRACT

A 22-year-old Japanese male, who was diagnosed with GATA2 deficiency two years ago, was admitted to our hospital complaining of a one-month history of fever and dry cough. A contrast-enhanced chest computed tomography (CT) scan revealed mediastinal lymphadenopathy. He was treated with broad-spectrum antibiotics, but this proved ineffective. Surgical lymph node biopsy was performed, and the resected mediastinal lymph node showed caseous necrosis, epithelioid cells, and macrophages histopathologically. Broad-spectrum antibiotics were administered on suspicion of nontuberculous mycobacteria (NTM) or tuberculosis lymphadenitis, and his general condition and mediastinal lymph node swelling deteriorated. At a later date, Mycobacterium kansasii was confirmed in the mediastinal lymph node culture. This case illustrates that in young patients with disseminated NTM infection or mediastinal lymphadenopathy due to NTM, GATA2 deficiency must be ruled out, and appropriate diagnosis and treatment should be considered.

KEYWORDS

GATA2 deficiency  Primary immunodeficiency  Mediastinal lymphadenopathy  Nontuberculous mycobacteria (NTM)  Mycobacterium kansasii 

Received 5 Mar 2020 / Accepted 11 Jun 2020

AJRS, 9(5): 383-387, 2020

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