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Abstract

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Article in Japanese

Case Report

A case of lung adenocarcinoma with anti-ARS antibody-positive interstitial lung disease

Noriaki Itoa,b  Hideto Oshitaa  Misato Senooa  Kunihiko Funaishia  Yasuyuki Mitamaa  Ken Okusakia 

aDepartment of Internal Medicine, Mihara Medical Association Hospital
bDepartment of Respiratory Medicine, Hiroshima University Hospital

ABSTRACT

A 67-year-old man was followed up for bilateral ground-glass opacification for three years. The consolidation appeared in the lower lobe of the right lung, and he was diagnosed with adenocarcinoma by bronchoscopy. In the course of examining for interstitial pneumonia he showed positive for rheumatoid factor and anti-aminoacyl tRNA synthetase (anti-ARS) antibodies, suggesting the involvement of an autoimmune disease. Although interstitial lung disease is frequently complicated by lung cancer, reports of anti-ARS antibody-positive interstitial lung disease with lung cancer are rare. There are many unclear points regarding the complication risks of both lung cancer and of drug therapy for lung cancer in interstitial pneumonia with autoimmune features, and it is an important subject for future study.

KEYWORDS

Anti-aminoacyl tRNA synthetase (anti-ARS) antibody  Interstitial pneumonia with autoimmune features (IPAF)  Lung cancer 

Received 8 May 2020 / Accepted 30 Jul 2020

AJRS, 9(6): 449-453, 2020

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