Ito Hiroyuki¹・Cascone Tina²・Provencio Mariano³・Sepesi Boris²・Lu Shun⁴・Aanur Nivedita⁵・Li Sunney⁵・Spicer Jonathan⁶
Kanagawa Cancer Center, Yokohama, Japan¹；The University of Texas MD Anderson Cancer Center, Houston, TX, USA²；Hospital Universitario Puerta de Hierro, Madrid, Spain³；Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China⁴；Bristol Myers Squibb, Princeton, NJ, USA⁵；McGill University, Montreal, Quebec, Canada⁶

Mitsudomi Tetsuya¹・Forde Patrick M.²・Spicer Jonathan³・Lu Shun⁴・Provencio Mariano⁵・Awad Mark M.⁶・Felip Enriqueta⁷・Broderick Stephen²・Brahmer Julie R.²・Swanson Scott J.⁶・Kerr Keith⁸・Wang Changli⁹・Saylors Gene B.¹⁰・Tanaka Fumihiro¹¹・Ito Hiroyuki¹²・Chen Ke-Neng¹³・Dorange Cecile¹⁴・Cai Junliang¹⁴・Fiore Joseph¹⁴・Girard Nicolas¹⁵
Kindai University Faculty of Medicine, Ohno-Higashi, Osaka-Sayama, Japan¹；Johns Hopkins Kimmel Cancer Center, Baltimore, MD, USA²；McGill University Health Center, Montreal, Quebec, Canada³；Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai JiaoTong University, Shanghai, China⁴；Hospital Universitario Puerta de Hierro, Madrid, Spain⁵；Dana-Farber Cancer Institute, Boston, MA, USA⁶；Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology, Barcelona, Spain⁷；Aberdeen Royal Infirmary, Aberdeen, UK⁸；Tianjin Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China⁹；Charleston Oncology, Charleston, SC, USA¹⁰；University of Occupational and Environmental Health, Kitakyushu, Japan¹¹；Kanagawa Cancer Center, Yokohama, Japan¹²；Peking University School of Oncology, Beijing Cancer Hospital, Beijing, China¹³；Bristol Myers Squibb, Princeton, NJ, USA¹⁴；Institut du Thorax Curie-Montsouris, Institut Curie, Paris, France¹⁵

Tanaka Fumihiro¹・Spicer Jonathan²・Wang Changli³・Saylors Gene B.⁴・Chen Ke-Neng⁵・Liberman Moishe⁶・Vokes Everett⁷・Girard Nicolas⁸・Lu Shun⁹・Provencio Mariano¹⁰・Mitsudomi Tetsuya¹¹・Awad Mark M.¹²・Felip Enriqueta¹³・Forde Patrick M.¹⁴・Swanson Scott J.¹²・Brahmer Julie R.¹⁴・Kerr Keith¹⁵・Dorange Cecile¹⁶・Cai Junliang¹⁶・Broderick Stephen¹⁴
University of Occupational and Environmental Health, Kitakyushu, Japan¹；McGill University Health Center, Montreal, Quebec, Canada²；Tianjin Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China³；Charleston Oncology, Charleston, SC, USA⁴；Peking University School of Oncology, Beijing Cancer Hospital, Beijing, China⁵；Centre hospitalier de l'Universite de Montreal, Montreal, Quebec, Canada⁶；University of Chicago Medicine, Chicago, IL, USA⁷；Institut du Thorax Curie-Montsouris, Institut Curie, Paris, France⁸；Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai JiaoTong University, Shanghai, China⁹；Hospital Universitario Puerta de Hierro, Madrid, Spain¹⁰；Kindai University Faculty of Medicine, Ohno-Higashi, Osaka-Sayama, Japan¹¹；Dana-Farber Cancer Institute, Boston, MA, USA¹²；Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology, Barcelona, Spain¹³；Johns Hopkins Kimmel Cancer Center, Baltimore, MD, USA¹⁴；Aberdeen Royal Infirmary, Aberdeen, UK¹⁵；Bristol Myers Squibb, Princeton, NJ, USA¹⁶

Sakai Hiroshi¹・Reck Martin²・Ciuleanu Tudor-Eliade³・Cobo Manuel⁴・Schenker Michael⁵・Zurawski Bogdan⁶・de Menezes Juliana Janoski⁷・Richardet Eduardo⁸・Bennouna Jaafar⁹・Felip Enriqueta¹⁰・Juan-Vidal Oscar¹¹・Alexandru Aurelia¹²・Scherpereel Arnaud¹³・Lu Shun¹⁴・Paz-Ares Luis G.¹⁵・Carbone David Paul¹⁶・Memaj Arteid¹⁷・Marimuthu Sathiya¹⁷・Tran Phuong¹⁷・John Thomas¹⁸
Saitama Cancer Center, Saitama, Japan¹；Airway Research Center North, German Center for Lung Research, LungClinic, Grosshansdorf, Germany²；Institutul Oncologic Prof Dr Ion Chiricuta and UMF Iuliu Hatieganu, Cluj-Napoca, Romania³；Unidad de Gestion Clinica Intercentros de Oncologia Medica, Hospitales Universitarios Regional y Virgen de la Victoria, IBIMA, Malaga, Spain⁴；SF Nectarie Oncology Center, Craiova, Romania⁵；Ambulatorium Chemioterapii, Bydgoszcz, Poland⁶；Hospital Nossa Senhora da Conceicao, Porto Alegre, Brazil⁷；Instituto Oncologico de Cordoba, Cordoba, Argentina⁸；University Hospital of Nantes and INSERM, CRCINA, Nantes, France⁹；Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology, Barcelona, Spain¹⁰；Hospital Universitario La Fe, Valencia, Spain¹¹；Institute of Oncology Prof Dr Alexandru Trestioreanu Bucha, Bucharest, Romania¹²；University of Lille, CHU Lille, INSERM U1189, OncoThAI, Lille, France¹³；Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai JiaoTong University, Shanghai, China¹⁴；Hospital Universitario 12 de Octubre, CNIO-H12o Lung Cancer Clinical Research Unit, Universidad Complutense ＆ CiberOnc, Madrid, Spain¹⁵；The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA¹⁶；Bristol Myers Squibb, Princeton, NJ, USA¹⁷；Austin Hospital, Heidelberg, VIC, Australia¹⁸

Nishio Makoto¹・Paz-Ares Luis G.²・Ciuleanu Tudor-Eliade³・Lee Jong-Seok⁴・Urban Laszlo⁵・Caro Reyes Bernabe⁶・Park Keunchil⁷・Sakai Hiroshi⁸・Ohe Yuichiro⁹・Pluzanski Adam¹⁰・Ramalingam Suresh S.¹¹・Brahmer Julie R.¹²・Borghaei Hossein¹³・O'Byrne Kenneth John¹⁴・Hellmann Matthew D.¹⁵・Memaj Arteid¹⁶・Sun Peng¹⁶・Reck Martin¹⁷
Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan¹；Hospital Universitario 12 de Octubre, CNIO-H12o Lung Cancer Clinical Research Unit, Universidad Complutense ＆ CiberOnc, Av. De Cordoba SN, 28041 Madrid, Spain²；Institutul oncologic Prof Dr Ion Chiricuta and UMF Iuliu Hatieganu, Cluj Napoca, Romania³；Seoul National University Bundang Hospital, Seongnam, Republic of Korea⁴；Matrai Gyogyintezet, Matrahaza, Hungary⁵；Hospital Universitario Virgen Del Rocio, Instituto de Biomedicina de Seville, Seville, Spain⁶；Samsung Medical Center at Sungkyunkwan University School of Medicine, Seoul, Republic of Korea⁷；Saitama Cancer Center, Saitama, Japan⁸；National Cancer Center Hospital, Chuo-ku, Tokyo Japan⁹；Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland¹⁰；Winship Cancer Institute, Emory University, Atlanta, GA, USA¹¹；Johns Hopkins Kimmel Cancer Center, Baltimore, MD, USA¹²；Fox Chase Cancer Center, Philadelphia, PA, USA¹³；Princess Alexandra Hospital, Brisbane, Australia¹⁴；Memorial Sloan Kettering Cancer Center, New York, NY, USA¹⁵；Bristol Myers Squibb, Princeton, NJ, USA¹⁶；Airway Research Center North, German Center for Lung Research, Grosshansdorf, Germany¹⁷

Izumi Hiroki¹・Owonikoko Taofeek K.²・Champiat Stéphane³・Johnson Melissa⁴・Govindan Ramaswamy⁵・Lai Victoria⁶・Borghaei Hossein⁷・Boyer Michael⁸・Boosman Rene J.⁹・Hummel Horst-Dieter¹⁰・Blackhall Fiona H.¹¹・Reguart Noemi¹²・Dowlati Afshin¹³・Zhang Yiran¹⁴・Mukherjee Sujoy¹⁴・Minocha Mukul¹⁴・Zhou Yanchen¹⁵・Shetty Aditya¹⁴・Sadraei Nooshin Hashemi¹⁴・Rodrigues Luis Paz-Ares¹⁶
Department of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan¹；Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, USA²；Drug Development Department（DITEP）Gustave Roussy, Paris-Saclay University, Villejuif, France³；Lung Cancer Research, Sarah Cannon Research Institute, Tennessee Oncology, Nashville, USA⁴；Divisions of Hematology and Oncology, Washington University Medical School, St. Louis, USA⁵；Thoracic Oncology Service, Department of Medicine, Division of Solid Tumor Oncology, Memorial Sloan Kettering Cancer Center, New York, USA⁶；Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, USA⁷；Chris O'Brien Lifehouse, Camperdown, Australia⁸；The Netherlands Cancer Institute, Amsterdam, Netherlands⁹；Translational Oncology/Early Clinical Trial Unit（ECTU）, Comprehensive Cancer Center Mainfranken, University Hospital Wuerzburg, Wuerzburg, Germany¹⁰；Department of Medical Oncology, The Christie NHS Foundation Trust, Division of Cancer Sciences, University of Manchester, Manchester, UK¹¹；Department of Medical Oncology, Hospital Barcelona, Barcelona, Spain¹²；Division of Hematology and Oncology, Department of Medicine, University Hospitals Seidman Cancer Center and Case Western Reserve University, Cleveland, USA¹³；Amgen Inc., Thousand Oaks, USA¹⁴；Amgen Inc., South San Francisco, USA¹⁵；Hospital Universitario 12 de Octubre, H120H120-CNIO Lung Cancer Clinical Research Unit, Universidad Complutense ＆ Ciberonc, Madrid, Spain¹⁶

*小暮　啓人¹・柏原　光介²・豆鞘　伸昭³・中村　　敦⁴・別所　昭宏⁵・安宅　信二⁶・滝口　裕一⁷・坂　　英雄¹・海老　規之⁸・井上　　彰⁹・倉田　宝保¹⁰・嘉田　明子¹・橋本　大哉¹¹・安藤　昌彦¹²・山本　信之¹³・弦間　昭彦¹⁴
名古屋医療センター¹；熊本地域医療センター²；静岡県立静岡がんセンター³；仙台厚生病院⁴；岡山赤十字病院⁵；近畿中央呼吸器センター⁶；千葉大学⁷；飯塚病院⁸；東北大学⁹；関西医科大学¹⁰；名古屋市立大学¹¹；名古屋大学¹²；和歌山県立医科大学¹³；日本医科大学¹⁴

*Kubota Kaoru¹・de Castro, Jr. Gilberto²・Kudaba Iveta³・Wu Yi-Long⁴・Lopes Gilberto⁵・Kowalski Dariusz M.⁶・Turna Hande Z.⁷・Caglevic Christian⁸・Zhang Li⁹・Karaszewska Boguslawa¹⁰・Laktionov Konstantin K.¹¹・Srimuninnimit Vichien¹²・Bondarenko Igor¹³・Mukherjee Rinee¹⁴・Lin Jianxin¹⁴・Souza Fabricio¹⁴・Mok Tony S. K.¹⁵・Cho Byoung Chul¹⁶
Department of Pulmonary Medicine and Oncology, Nippon Medical School Hospital, Tokyo, Japan¹；Instituto do Câncer do Estado de São Paulo, São Paulo, Brazil²；Latvian Oncology Center, Riga East Clinical University, Riga, Latvia³；Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital ＆ Guangdong Academy of Medical Sciences, China⁴；Department of Medical Oncology, Sylvester Comprehensive Cancer Center at the University of Miami, FL, USA⁵；Department of Lung Cancer and Chest Tumours, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland⁶；Department of Internal Medicine, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey⁷；Cancer Research Department, Instituto Oncologico Fundacion Arturo Lopez Perez, Santiago, Chile⁸；Peking Union Medical College Hospital, Beijing, China⁹；Przychodnia Lekarska KOMED, Konin, Poland¹⁰；Federal State Budgetary Institution“N.N. Blokhin National Medical Research Center of Oncology”of the Ministry of Health of the Russian Federation（N.N Blokhin NMRCO）, Moscow, Russia¹¹；Department of Medicine, Siriraj Hospital, Bangkok, Thailand¹²；Oncology and Medical Radiology Department, Dnipro State Medical University, Dnipro, Ukraine¹³；Merck ＆ Co., Inc., Kenilworth, NJ, USA¹⁴；Clinical Oncology, State Key Laboratory of Translational Oncology, Chinese University of Hong Kong, Shatin, Hong Kong, China¹⁵；Division of Medical Oncology, Yonsei Cancer Center, Seoul, South Korea¹⁶

*加藤　晃史¹・on behalf of the PACIFIC Study investigators²
神奈川県立がんセンター呼吸器内科¹；その他²

*戸井　之裕¹・武内　　進²・菅原　俊一¹・手良向　聡³・野呂林太郎²・藤川　　桂³・廣瀬　　敬⁴・安宅　信二⁵・南　　誠剛⁶・飯田慎一郎⁷・倉石　　博⁸・相羽　智生¹・河原　正明⁹・峯岸　裕司²・松本　　優²・清家　正博²・弦間　昭彦²・久保田　馨²
仙台厚生病院呼吸器内科¹；日本医科大学大学院医学研究科呼吸器内科学分野²；京都府立医科大学大学院医学研究科生物統計学³；日本医科大学多摩永山病院呼吸器・腫瘍内科⁴；国立病院機構近畿中央呼吸器センター呼吸器腫瘍内科⁵；大阪警察病院呼吸器内科⁶；国家公務員共済組合連合会大手前病院呼吸器内科⁷；長野赤十字病院呼吸器内科・感染症内科⁸；一般社団法人日本・多国間臨床試験機構⁹

*安藤　雄一
名古屋大学医学部附属病院化学療法部

*Minchom Anna¹・Tan Daniel²・*Massarelli Erminia³・Subbiah Vivek⁴・Boni Valentina⁵・Robinson Bruce⁶・Wirth Lori⁷・Hess Lisa M⁸・Huang Xin⁹・Kherani Jennifer⁹・Olek Elizabeth⁹・McCoach Caroline¹⁰・*Tanizawa Yoshinori¹¹
Royal Marsden Hospital and The Institute of Cancer Research, London, United Kingdom¹；National Cancer Centre, Singapore²；City of Hope, Duarte, USA³；MD Anderson Cancer Center, Houston, USA⁴；Start Center for Cancer Care, Madrid, Spain⁵；Royal North Shore Hospital, Sydney, Australia⁶；Massachusetts General Hospital, Boston, USA⁷；Eli Lilly and Company, Indianapolis, USA⁸；Loxo Oncology, a wholly-owned subsidiary of Eli Lilly and Company, Stamford, USA⁹；University of California at San Francisco, USA¹⁰；Eli Lilly Japan K.K., Kobe, Japan¹¹

Nishio Makoto¹・Jänne Pasi A.²・Baik Christina³・Su Wu-Chou⁴・Johnson Melissa L.⁵・Hayashi Hidetoshi⁶・Kim Dong-Wan⁷・Koczywas Marianna⁸・Gold Kathryn⁹・Steuer Conor¹⁰・Murakami Haruyasu¹¹・Yang James C. H.¹²・Kim Sang-We¹³・Vigliotti Michele¹⁴・Qi Zhenhao¹⁴・Qiu Yang¹⁴・Zhao Lihui¹⁴・Sternberg David¹⁴・Yu Channing¹⁴・Yu Helena A.¹⁵
The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Koto-ku, Japan¹；Dana-Farber Cancer Institute, Boston, MA²；Seattle Cancer Care Alliance, Seattle, WA³；National Cheng Kung University Hospital, Tainan, Taiwan⁴；Sarah Cannon Research Institute/Tennessee Oncology, PLCC, Nashville, TN⁵；Kindai University Hospital, Osaka-Sayama City, Japan⁶；Seoul National University Hospital, Seoul, South Korea⁷；City of Hope Medical Center, Duarte, CA⁸；University of California, San Diego, San Diego, CA⁹；Emory University Hospital, Atlanta, GA¹⁰；Shizuoka Cancer Center, Sunto-gun, Japan¹¹；National Taiwan University Cancer Center, Taipei, Taiwan¹²；University of Ulsan College of Medicine, Seoul, South Korea¹³；Daiichi Sankyo, Inc., Basking Ridge, NJ¹⁴；Memorial Sloan Kettering Cancer Center, New York, NY¹⁵

Winfree Katherine B¹・Molife Cliff¹・Peterson Patrik¹・Chen Yanyun¹・Visseren-Grul Carla¹・Leusch Mark¹・Beyrer Julie¹・Dimou Anastasios²・*Matsui Tomoko³
Eli Lilly and Company, Indianapolis, USA¹；Mayo Clinic, MN, USA²；Eli Lilly Japan K.K., Kobe, Japan³

Kato Terufumi¹・Skoulidis Ferdinandos²・Li Bob T.³・Govindan Ramaswamy⁴・Dy Grace K.⁵・Shapiro Geoffrey⁶・Bauml Joshua⁷・Schuler Martin H.⁸・Addeo Alfredo⁹・Besse Benjamin¹⁰・Anderson Abraham¹¹・Ang Agnes¹¹・Ngarmchamnanrith Gift¹¹・Tran Qui¹¹・Velcheti Vamsidhar¹²
Department of Thoracic Oncology, Kanagawa Cancer Center, Yokohama, Japan¹；The University of Texas MD Anderson Cancer Center, Cambridge, United Kingdom²；Memorial Sloan Kettering Cancer Center New York, USA³；Washington University School of Medicine, St. Louis, USA⁴；Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA⁵；Dana-Farber Cancer Institute Early Drug Development Center, Boston, USA⁶；Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA⁷；West German Cancer Centre, University Hospital Essen, Essen, Germany⁸；Medical Oncology, Geneva University Hospital, Geneva, Switzerland⁹；Department of Medicine and Thoracic Pathology Committee, Gustave Roussy, Villejuif, France¹⁰；Amgen Inc. Thousand Oaks, CA, USA¹¹；NYU Langone, Perlmutter Cancer Center, New York, USA¹²