*Fumihiro Tanaka¹・Hiroyuki Ito²・Morihito Okada³・Shunichi Sugawara⁴・Yutaka Shio⁵・Keisuke Tomii⁶・Jiro Okami⁷・Noriaki Sakakura⁸・Kaoru Kubota⁹・Kazuya Takamochi¹⁰・Shinji Atagi¹¹・Masahiro Tsuboi¹²・Satoshi Oizumi¹³・Norihiko Ikeda¹⁴・Yasuhisa Ohde¹⁵・Ives Ntambwe¹⁶・Javed Mahmood¹⁶・Junliang Cai¹⁶・Tetsuya Mitsudomi¹⁷
University Of Occupational And Environmental Health Hospital, Kitakyushu, Fukuoka, Japan¹；Kanagawa Cancer Center, Yokohama, Kanagawa, Japan²；Hiroshima University Hospital, Minami-Ku Hiroshima, Japan³；Sendai Kousei Hospital, Sendai, Miyagi, Japan⁴；Fukushima Medical University Hospital, Hikarigaoka, Fukushima, Japan⁵；Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan⁶；Osaka International Cancer institute, Osaka city, Osaka, Japan⁷；Aichi Cancer Center Hospital, Nagoya, Aichi, Japan⁸；Nippon Medical School Hospital, Bunkyo City, Tokyo, Japan⁹；Juntendo University Hospital, Tokyo, Japan¹⁰；National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Osaka, Japan¹¹；National Cancer Center Hospital East, Kashiwa, Chiba, Japan¹²；Hokkaido Cancer Center, Sapporo, Hokkaido, Japan¹³；Tokyo Medical University Hospital, Shinjuku City, Tokyo, Japan¹⁴；Shizuoka Cancer Center, Sunto District, Shizuoka, Japan¹⁵；WW Medical Oncology, Bristol Myers Squibb, Princeton, NJ, USA¹⁶；Kindai University Hospital Osakasayama, Osaka, Japan¹⁷

*Takayasu Kurata¹・Naoyuki Nogami²・Hideo Saka³・Makoto Nishio⁴・Takaaki Tokito⁵・Toshiaki Takahashi⁶・Kazuo Kasahara⁷・Yoshihiro Hattori⁸・Eiki Ichihara⁹・Noriaki Adachi¹⁰・Kazuo Noguchi¹⁰・Paul Schwarzenberger¹¹・Hidehito Horinouchi¹²
Department of Thoracic Oncology, Kansai Medical University, Osaka, Japan¹；Department of Community Medicine, Pulmonology and Cardiology, Ehime University Graduate School of Medicine, Toon, Japan²；Department of Respiratory Medicine and Medical Oncology, National Hospital Organization Nagoya Medical Center, Nagoya, Japan³；Department of Thoracic Medical Oncology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan⁴；Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan⁵；Division of Thoracic Oncology, Shizuoka Cancer Center, Shuntougun, Japan⁶；Department of Respiratory Medicine, Kanazawa University Hospital, Kanazawa, Japan⁷；Department of Thoracic Oncology, Hyogo Cancer Center, Akashi, Japan⁸；Department of Allergy and Respiratory Medicine, Okayama University Hospital, Okayama, Japan⁹；MSD K.K., Tokyo, Japan¹⁰；Merck ＆ Co., Inc., Rahway, NJ, USA¹¹；Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan¹²

*Nobuyuki Yamamoto¹・Terufumi Kato²・Isamu Okamoto³・Fumio Imamura⁴・Makoto Nishio⁵・Shinji Atagi⁶・Tomonori Hirashima⁷・Hiroshi Tanaka⁸・Tatsuro Fukuhara⁹・Yasuharu Nakahara¹⁰・Nobuyuki Katakami¹¹・Morihito Okada¹²・Takayasu Kurata¹³・Hidehito Horinouchi¹⁴・Hibiki Udagawa¹⁵・Kazuo Kasahara¹⁶・Noriaki Adachi¹⁷・Kazuo Noguchi¹⁷・Paul Schwarzenberger¹⁸・Shunichi Sugawara¹⁹
Wakayama Medical University, Wakayama, Japan¹；Kanagawa Cancer Center, Yokohama, Japan²；Kyushu University, Fukuoka, Japan³；Osaka International Cancer Institute, Osaka, Japan⁴；The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan⁵；National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Japan⁶；Osaka Habikino Medical Center, Osaka, Japan⁷；Niigata Cancer Center Hospital, Niigata, Japan⁸；Miyagi Cancer Center, Natori, Japan⁹；Himeji Medical Center, Himeji, Japan¹⁰；Takarazuka City Hospital, Takarazuka, Japan¹¹；Hiroshima University, Hiroshima, Japan¹²；Kansai Medical University, Osaka, Japan¹³；National Cancer Center Hospital, Tokyo, Japan¹⁴；National Cancer Center Hospital East, Kashiwa, Japan¹⁵；Kanazawa University Hospital, Ishikawa, Japan¹⁶；MSD K.K., Tokyo, Japan¹⁷；Merck ＆ Co., Inc., Rahway, NJ, USA¹⁸；Sendai Kousei Hospital, Miyagi, Japan¹⁹

*Hideaki Mizutani¹・Kazuo Kasahara²・Keisuke Tomii³・Shuji Murakami⁴・Hidehito Hayashi⁵・Hiroyasu Kaneda⁶・Makoto Maemondo⁷・Koichi Minato⁸・Tetsuji Kawamura⁹・Yuki Misumi¹⁰・Takeshi Hisada¹¹・Miyako Satouchi¹²・Katsuyuki Hotta¹³・Nan Hu¹⁴・Xiaoqing Zhang¹⁴・Judi Sylvester¹⁴・Satoshi Ikeda¹⁵
Saitama Cancer Center, Saitama, Japan¹；Kanazawa University Hospital, Kanazawa, Japan²；Kobe City Medical Center General Hospital, Kobe, Japan³；Kanagawa Cancer Center, Kanagawa, Japan⁴；Kindai University Hospital, Osaka, Japan⁵；Osaka Metropolitan University Hospital, Osaka, Japan⁶；Iwate Medical University Hospital, Iwate, Japan⁷；Gunma Prefectural Cancer Center, Gunma, Japan⁸；National Hospital Organization Himeji Medical Center, Himeji, Japan⁹；Yokohama Municipal Citizen's Hospital, Yokohama, Japan¹⁰；Gunma University Hospital, Gunma, Japan¹¹；Hyogo Cancer Center, Hyogo, Japan¹²；Okayama University Hospital, Okayama, Japan¹³；Bristol Myers Squibb, Princeton, NJ, USA¹⁴；Kanagawa Cardiovascular and Respiratory Center, Kanagawa, Japan¹⁵

*Makoto Nishio¹・Yuichiro Ohe²・Satoshi Ikeda³・Toshihide Yokoyama⁴・Hidetoshi Hayashi⁵・Tatsuro Fukuhara⁶・Yuki Sato⁷・Hiroshi Tanaka⁸・Katsuyuki Hotta⁹・Shunichi Sugawara¹⁰・Haruko Daga¹¹・Isamu Okamoto¹²・Kazuo Kasahara¹³・Tateaki Naito¹⁴・Li Li¹⁵・Ravi G. Gupta¹⁵・Judith Bushong¹⁵・Hideaki Mizutani¹⁶
Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan¹；National Cancer Center Hospital, Chuo City, Tokyo, Japan²；Kanagawa Cardiovascular and Respiratory Center, Kanagawa, Japan³；Kurashiki Central Hospital, Kurashiki, Okayama, Japan⁴；Kindai University Hospital, Osaka, Japan⁵；Miyagi Cancer Center, Natori, Miyagi, Japan⁶；Department of Respiratory Medicine, Kobe City Medical Center General Hospital, Kobe, Japan⁷；Niigata Cancer Center Hospital, Chuo Ward, Niigata, Japan⁸；Okayama University Hospital, Okayama, Japan⁹；Sendai Kousei Hospital, Sendai, Miyagi, Japan¹⁰；Osaka City General Hospital, Miyakojima Ward, Osaka, Japan¹¹；Kyushu University Hospital, Higashi Ward, Fukuoka, Japan¹²；Kanazawa University Hospital, Kanazawa, Ishikawa, Japan¹³；Shizuoka Cancer Center, Nagaizumi, Shizuoka, Japan¹⁴；Bristol Myers Squibb, Princeton, NJ, USA¹⁵；Saitama Cancer Center, Saitama, Japan¹⁶

*阪本　智宏¹・松原　太一²・高濱　隆幸³・横山　俊秀⁴・中村　　敦⁵・時任　高章⁶・岡本　龍郎⁷・赤松　弘朗⁸・沖　　昌英⁹・佐藤　悠城¹⁰・飛野　和則¹¹・西村　邦裕¹²・平岡　　学¹³・釼持　広知¹⁴・藤本　淳也¹⁵・下川　元継¹⁶・山本　信之⁸・中川　和彦³
鳥取大学¹；北九州市立医療センター²；近畿大学³；倉敷中央病院⁴；仙台厚生病院⁵；久留米大学⁶；九州がんセンター⁷；和歌山県立医科大学⁸；名古屋医療センター⁹；神戸中央市民病院¹⁰；飯塚病院¹¹；株式会社テンクー¹²；武田薬品工業株式会社¹³；静岡がんセンター¹⁴；MD Anderson Cancer Center¹⁵；山口大学¹⁶

*Koichi Goto¹・Catherine A. Shu²・Yuichiro Ohe³・Benjamin Besse⁴・Se-Hoon Lee⁵・Yongsheng Wang⁶・Frank Griesinger⁷・James Chih-Hsin Yang⁸・Enriqueta Felip⁹・Rachel E. Sanborn¹⁰・Reyes Bernabe Caro¹¹・Joshua C. Curtin¹²・Jun Chen¹²・Janine Mahoney¹²・Leonardo Trani¹²・Joshua M. Bauml¹²・Roland E. Knoblauch¹²・Meena Thayu¹²・Byoung Chul Cho¹³
National Cancer Center Hospital East, Kashiwa, Japan¹；Columbia University Medical Center, New York, NY, USA²；National Cancer Center Hospital, Tokyo, Japan³；Paris-Sacaly University, Institut Gustave Roussy, Villejuif, France⁴；Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea⁵；West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China⁶；Pius-Hospital, University of Oldenburg, Oldenburg, Germany⁷；National Taiwan University Cancer Center, Taiwan⁸；Vall d'Hebron University Hospital and Vall d'Hebron Institute of Oncology, Barcelona, Spain⁹；Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA¹⁰；Hospital Universitario Virgen Del Rocio, Seville, Spain¹¹；Janssen Research and Development, Spring House, PA, USA¹²；Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea¹³

*Ryo Toyozawa¹・Tatsuya Yoshida²・Toru Kumagai³・Makoto Nishio⁴・Takashi Seto⁵・Koichi Goto⁶・Kazuhiko Nakagawa⁷・Yuichiro Ohe²・Kentarou Kudou⁸・Takayuki Asato⁸・Pingkuan Zhang⁹・Nobuyuki Yamamoto¹⁰
National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan¹；National Cancer Center Hospital, Tokyo, Japan²；Osaka International Cancer Institute, Osaka, Japan³；The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan⁴；National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan⁵；National Cancer Center Hospital East, Kashiwa, Japan⁶；Kindai University Faculty of Medicine, Osaka-Sayama, Japan⁷；Takeda Pharmaceutical Company Limited, Osaka, Japan⁸；Takeda Development Center Americas, Inc., Lexington, MA, USA⁹；Wakayama Medical University, Wakayama, Japan¹⁰

*Hiroshi Sakai¹・Masahiro Morise²・Terufumi Kato³・Shingo Matsumoto⁴・Takako Inoue⁵・Tomohiro Sakamoto⁶・Takaaki Tokito⁷・Shinji Atagi⁸・Toshiyuki Kozuki⁹・Hiroaki Takeoka¹⁰・Kenichi Chikamori¹¹・Naofumi Shinagawa¹²・Hiroshi Tanaka¹³・S Peter Eggleton¹⁴・Rolf Bruns¹⁵・Gordon Otto¹⁴・Paul K. Paik^16,17
Department of Thoracic Oncology, Ageo Central General Hospital, Ageo, Saitama, Japan¹；Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan²；Department of Thoracic Oncology, Kanagawa Cancer Center, Yokohama, Japan³；Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa City, Japan⁴；Department of Thoracic Oncology, Osaka International Cancer Institute, Osaka, Japan⁵；Department of Respiratory Medicine, Tottori University Hospital, Yonago City, Japan⁶；Department of Internal Medicine, Kurume University School of Medicine, Kurume City, Japan⁷；Health Management Center, JCHO Yamatokoriyama Hospital, Yamatokoriyama City, Japan⁸；Department of Respiratory Medicine, NHO Shikoku Cancer Center, Matsuyama City, Japan⁹；Department of Respiratory Medicine, NHO Kyushu Medical Center, Fukuoka City, Japan¹⁰；Department of Oncology, NHO Yamaguchi - Ube Medical Center, Ube City, Japan¹¹；Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan¹²；Department of Internal Medicine, Niigata Cancer Center Hospital, Niigata City, Japan¹³；Global Clinical Development, Merck Healthcare KGaA, Darmstadt, Germany¹⁴；Department of Biostatistics, Merck Healthcare KGaA, Darmstadt, Germany¹⁵；Department of Medicine, Thoracic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA¹⁶；Department of Medicine, Weill Cornell Medical College, New York, NY, USA¹⁷

*Kazuto Nishio¹・Kazuko Sakai¹・Makoto Nishio²・Takashi Seto³・Carla Visseren-Grul⁴・Michelle Carlsen⁵・Sotaro Enatsu⁶・Tomoko Matsui⁶・Kazuhiko Nakagawa⁷
Department of Genome Biology, Kindai University Faculty of Medicine, Osaka, Japan¹；Department of Thoracic Medical Oncology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan²；National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan³；Eli Lilly Netherlands, Utrecht, The Netherlands⁴；Eli Lilly and Company, Indianapolis, Indiana, USA⁵；Eli Lilly Japan K.K., Kobe, Japan⁶；Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka, Japan⁷