*白石　祥理^1,2・岡本　　勇^1,2
九州大学病院¹；西日本がん研究機構（WJOG）²

*Takashi Kijima¹・Hisao Imai²・Koichi Azuma³・Kazuma Kishi⁴・Haruhiro Saito⁵・Teppei Yamaguchi⁶・Hidetoshi Hayashi⁷・Yoshimasa Shiraishi⁸・Kohei Fujita⁹・Satoshi Watanabe¹⁰・Satoru Kitazono¹¹・Tatsuro Fukuhara¹²・Osamu Hataji¹³・Yukihiro Toi¹⁴・Hideaki Mizutani¹⁵・Yusuke Hamakawa¹⁶・Makoto Maemondo¹⁷・Tomoyuki Ohsugi¹⁸・Keisuke Suzuki¹⁹・Hidehito Horinouchi²⁰・Yuichiro Ohe²⁰
Department of Respiratory Medicine and Hematology, Hyogo Medical University, School of Medicine, Hyogo, Japan¹；Department of Respiratory Medicine, Comprehensive Cancer Center, International Medical Center, Saitama Medical University, Saitama, Japan²；Division of Respirology, Neurology and Rheumatology, Department of Internal Medicine, Kurume University, School of Medicine, Fukuoka, Japan³；Department of Respiratory Medicine, Toho University Omori Medical Center, Tokyo, Japan⁴；Department of Thoracic Oncology, Kanagawa Cancer Center, Kanagawa, Japan⁵；Department of Thoracic Oncology, Aichi Cancer Center Hospital, Aichi, Japan⁶；Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka, Japan⁷；Department of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan⁸；Division of Respiratory Medicine, National Hospital Organization Kyoto Medical Center, Kyoto, Japan⁹；Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan¹⁰；Department of Thoracic Medical Oncology, the Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan¹¹；Department of Respiratory Medicine, Miyagi Cancer Center, Miyagi, Japan¹²；Respiratory Center, Matsusaka Municipal Hospital, Mie, Japan¹³；Department of Pulmonary Medicine, Sendai Kousei Hospital, Miyagi, Japan¹⁴；Department of Thoracic Oncology, Saitama Cancer Center, Saitama, Japan¹⁵；Department of Respiratory Medicine, Yokohama Municipal Citizen's Hospital, Yokohama, Kanagawa, Japan¹⁶；Division of Pulmonary Medicine, Department of Internal Medicine, Iwate Medical University School of Medicine, Iwate, Japan¹⁷；Bristol-Myers Squibb K.K., Japan¹⁸；Ono Pharmaceutical Co., Ltd., Japan¹⁹；Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan²⁰

*Terufumi Kato¹・Hirotsugu Kenmotsu²・Shunichi Sugawara³・Yuki Sato⁴・Kyoichi Okishio⁵・Hisayoshi Hashimoto⁶・Kanae Motoyama⁶・Yohji Itoh⁷・Ana Bolanos⁸・Masahiro Tsuboi⁹
Department of Thoracic Oncology, Kanagawa Cancer Center, Yokohama, Japan¹；Division of Thoracic Oncology, Shizuoka Cancer Center, Nagaizumi-cho Sunto-gun, Shizuoka, Japan²；Sendai Kousei Hospital, Hirosemachi, Aoba-ku, Sendai City, Miyagi Prefecture, Japan³；Department of Respiratory Medicine, Kobe City Medical Center General Hospital, Minatojima Minamimachi, Chuo-ku, Kobe, Hyogo, Japan⁴；Department of Thoracic Oncology, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Osaka, Japan⁵；Oncology Research and Development, AstraZeneca, Japan⁶；Biometrics, AstraZeneca, Japan⁷；Oncology Research and Development, AstraZeneca, Mississauga, Canada⁸；Department of Thoracic Surgery and Oncology, National Cancer Center Hospital East, Kashiwa, Japan⁹

*Masahiro Tsuboi¹・Luis Paz-Ares²・Mary O'Brien³・Murielle Mauer⁴・Urania Dafni⁵・Morihito Okada⁶・Kenji Sugio⁷・Tetsuya Mitsudomi⁸・Hisashi Saji⁹・Yukitoshi Satoh¹⁰・Noriaki Sakakura¹¹・Koichi Azuma¹²・Kersti Oselin¹³・Emilio Esteban¹⁴・Dolores Isla¹⁵・Alex Martinez-Marti¹⁶・Martin Faehling¹⁷・Jong-Seok Lee¹⁸・Nitish Jha⁴・Steven M. Keller¹⁹・Tomoko Mori²⁰・Noriaki Adachi²⁰・Sandrine Marreaud⁴・Rolf Stahel²¹・Solange Peters²²・Benjamin Besse²³・Kazuhiko Nakagawa²⁴
National Cancer Center Hospital East, Kashiwa, Japan¹；Hospital Universitario 12 de Octubre, CNIO, Ciberonc ＆ Universidad Complutense, Madrid, Spain²；Royal Marsden Hospital, London, UK³；European Organisation for Research and Treatment of Cancer, Headquarters Brussels, Belgium⁴；National and Kapodistrian University of Athens and Frontier Science Foundation Hellas, Athens, Greece⁵；Hiroshima University Hospital, Hiroshima, Japan⁶；Oita University Hospital, Oita, Japan⁷；Kindai University Hospital, Osaka, Japan⁸；St. Marianna University School of Medicine Hospital, Kawasaki, Japan⁹；Kitasato University Hospital, Sagamihara, Japan¹⁰；Aichi Cancer Center Hospital, Nagoya, Japan¹¹；Kurume University Hospital, Kurume, Japan¹²；North Estonia Medical Centre, Tallinn, Estonia¹³；Hospital Universitario Central de Asturias, Oviedo, Spain¹⁴；University Hospital Lozano Blesa, IIS Aragon, Zaragoza, Spain¹⁵；Vall d'Hebron Institute of Oncology（VHIO）, Vall d'Hebron University Hospital, Barcelona, Spain¹⁶；Klinikum Esslingen, Esslingen, Germany¹⁷；Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea¹⁸；Merck ＆ Co., Inc., Rahway, NJ, USA¹⁹；MSD K.K., Tokyo, Japan²⁰；European Thoracic Oncology Platform, Bern, Switzerland²¹；Lausanne University Hospital, Lausanne, Switzerland²²；Institut Gustave Roussy, Villejuif, France²³；Kindai University Faculty of Medicine, Osaka, Japan²⁴

*Tetsuya Mitsudomi¹・Hiroyuki Ito²・Morihito Okada³・Shunichi Sugawara⁴・Yutaka Shio⁵・Keisuke Tomii⁶・Jiro Okami⁷・Noriaki Sakakura⁸・Kaoru Kubota⁹・Kazuya Takamochi¹⁰・Shinji Atagi¹¹・Masahiro Tsuboi¹²・Satoshi Oizumi¹³・Norihiko Ikeda¹⁴・Yasuhisa Ohde¹⁵・Ives Ntambwe¹⁶・Junliang Cai¹⁶・Javed Mahmood¹⁶・Fumihiro Tanaka¹⁷
Kindai University Hospital, Osakasayama, Osaka, Japan¹；Kanagawa Cancer Center, Yokohama, Kanagawa, Japan²；Hiroshima University Hospital, Minami-Ku Hiroshima, Japan³；Sendai Kousei Hospital, Sendai, Miyagi, Japan⁴；Fukushima Medical University Hospital, Hikarigaoka, Fukushima, Japan⁵；Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan⁶；Osaka International Cancer institute, Osaka, Japan⁷；Aichi Cancer Center Hospital, Nagoya, Aichi, Japan⁸；Nippon Medical School Hospital, Bunkyo City, Tokyo, Japan⁹；Juntendo University Hospital, Bunkyo City, Tokyo, Japan¹⁰；National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Osaka, Japan（affiliation at the time of study）¹¹；National Cancer Center Hospital East, Kashiwa, Chiba, Japan¹²；Hokkaido Cancer Center, Sapporo, Hokkaido, Japan¹³；Tokyo Medical University Hospital, Shinjuku City, Tokyo, Japan¹⁴；Shizuoka Cancer Center, Sunto District, Shizuoka, Japan¹⁵；Bristol Myers Squibb, Princeton, NJ, USA¹⁶；University Of Occupational And Environmental Health Hospital, Kitakyushu, Fukuoka, Japan¹⁷