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Vol.37 No.1 contents | Japanese/English |
- Original Article -
Analysis of Serum Granulocyte-Colony Stimulating Factor (G-CSF) and G-CSF Production in Lung Cancer with Leukocytosis
Ikuma Kasuga, Yuichi Ichinose, Makoto Yonemaru, Harubumi Katoh* and Keisuke ToyamaThe First Department of Internal Medicine, and *The First Department of Surgery, Tokyo Medical College
In a study of 147 lung cancer patients during a 5-year period, 77 had leukocytosis (WBC>9,000/mm3). In 33 of 77 patients, no obvious infection or bone marrow metastasis was recognized. In 11 (7.5%) of 147 patients, marked leukocytosis (WBC>20,000/mm3) was recognized. In 6 (4.1%) of 147 patients, the leukocyte count showed more than 30,000/mm3. In order to determine the constructive expression of granulocyte-colony stimulating factor (G-CSF), we analyzed serum G-CSF activity in these patients using enzyme immunoassay. Of the 33 patients, 6 had high levels of G-CSF, consisting of each 2 cases of large cell carcinoma, adenocarcinoma, and squamous cell carcinoma. All 6 were histologically undifferentiated or poorly differentiated type. However, no case of small cell lung carcinoma showed a high G-CSF level. We immunohistochemically detected production of G-CSF in three cases consisting of one undifferentiated large cell carcinoma, one poorly differentiated squamous cell carcinoma, and one poorly differentiated adenocarcinoma.
key words: Lung cancer, Non-small cell lung cancer, Large cell cancer, Leukocytosis, Granulocyte-colony stimulating factor (G-CSF)
Received: June 28, 1996
Accepted: January 17, 1997
JJLC 37 (1): 61-66, 1997
