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Vol.37 No.7 contents | Japanese/English |
- Original Article -
Two-year Survival after chemotherapy in Patients with Stage IIIB or IV Adenocarcinoma of the Lung Evaluated using Quality-adjusted Survival Analysis
Akihisa Fujita, Hirotsugu Takabatake, Shigeru Tagaki and Kyuichirou SekineDivision of Respiratory Disease, Hokkaido Keiaikai Minami-ichijo Hospital
We evaluated the characteristics of 2-year survivors among 146 patients with stage IIIB or IV adenocarcinoma of the lung admitted to our hospital from 1986-1994. Twenty-five patients were survived over 2 years. Univariate prognostic factor analysis for 2-year survivors identified a good performance status as significant. Two-year survivors showed a higher response rate and underwent repeated treatments. We evaluated the effect of chemotherapy on QOL in 2-year survivors by quality-adjusted survival analysis known as a Q-TWiST (Quality adjusted Time Without Symptoms and Toxicity) analysis. If ut was nearly 0, namely toxicity due to chemotherapy was severe, mean Q-TWiST at 2 years of follow was approximately 70% of the value when healthy.
key words: Adenocarcinoma, Chemotherapy, 2-year survivor, Quality-adjusted survival analysis
Received: March 31, 1997
Accepted: November 11, 1997
JJLC 37 (7): 973-980, 1997
