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Vol.37 No.7 contents | Japanese/English |
- Case Report -
An Elderly Case of Small-Cell Lung Cancer Treated with Etoposide plus Carboplatin using Chatelut Formula
Minoru Fukuda, Mikio Oka, Kenji Terashi, Fumihiko Narasaki, Seiji Nagashima and Shigeru KohnoSecond Department of Internal Medicine, Nagasaki University School of Medicine
An 81-year-old man was admitted to our hospital and complaining of cough and dyspnea. Chest X-ray and CT showed a consolidation in right S8 and S9, hilar and mediastinal lymph node swelling, and emphysema. Small-cell lung carcinoma (SCLC) was diagnosed by cytological examination of sputum and bronchial washing from the right B9a. The clinical stage was evaluated for extensive disease (T4N2M0). Because of his age and renal dysfunction, four cycles of combination chemotherapy with etoposide (75 mg/m2, days1-3) plus carboplatin (target AUC=5, day 1) using the Chatelut formula were performed. The total tumor volume was reduced to 30% and a partial response was achieved. Actual carboplatin AUC at the first cycle was 4.42 mg.min/ml, which was slightly lower than the target AUC. Manageable bone marrow suppression in combination with G-CSF and less toxicity including renal injury, nausea/vomiting, and appetite loss were observed. This regimen is potentially feasible and effective for elderly or renal function-impaired patients with SCLC.
key words: Small cell lung cancer, Chatelut formula, Carboplatin, Chemotherapy, Elderly lung cancer
Received: August 11, 1997
Accepted: September 16, 1997
JJLC 37 (7): 1009-1015, 1997
